 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 7, 3935-3944, Copyright © 1987 by Society for Neuroscience
The neostriatal mosaic: III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems
CR Gerfen, KG Baimbridge and J Thibault
Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20892.
In the previous paper (Gerfen et al., 1987) mesostriatal dopaminergic
neurons were shown to be subdivided into dorsal and ventral tiers that
project to the striatal matrix and patch compartments, respectively. The
present study provides experimental evidence that these patch- matrix
mesostriatal dopaminergic systems are biochemically and developmentally
distinct. A 28 kDa calcium-binding protein (CaBP, or calbindin-D28 kDa) is
expressed in dorsal tier mesostriatal dopaminergic neurons. The
distribution of such neurons, located in the ventral tegmental area, dorsal
tier of the substantia nigra pars compacta, and retrorubral area, matches
that of dopaminergic neurons that project to the striatal matrix.
Dopaminergic neurons that do not express CaBP--those in the ventral tier of
the pars compacta and in the pars reticulata--are distributed in a pattern
that matches the origin of the dopaminergic projection to the striatal
patches. During development, dopaminergic afferents to the striatal patch
compartment are in place prior to the development of those to the matrix.
Injections of the neurotoxin 6-hydroxydopamine (6-OHDA) into the striatum
of newborn rats result in a selective and long-lasting depletion of
dopaminergic afferents in the striatal patches. The later- developing
matrix projection is relatively spared by such lesions. The distribution of
surviving dopaminergic neurons, labeled with tyrosine hydroxylase (TH)
immunoreactivity, matches the pattern of dorsal tier neurons previously
shown to provide inputs to the matrix. Surviving neurons also express CaBP
immunoreactivity and have dendrites that spread mediolaterally, in the
plane of the pars compacta. On the other hand, those neurons that project
to the patches are selectively lesioned by the neonatal 6-OHDA striatal
injections, do not express CaBP, and have dendrites that are directed
ventrally into the pars reticulata.
This article has been cited by other articles:
|
|
|
|
 
M. Joksimovic, A. Anderegg, A. Roy, L. Campochiaro, B. Yun, R. Kittappa, R. McKay, and R. Awatramani
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
PNAS,
November 10, 2009;
106(45):
19185 - 19190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Foehring, X. F. Zhang, J.C.F. Lee, and J. C. Callaway
Endogenous Calcium Buffering Capacity of Substantia Nigral Dopamine Neurons
J Neurophysiol,
October 1, 2009;
102(4):
2326 - 2333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. C. Brown, P. Henny, J. P. Bolam, and P. J. Magill
Activity of Neurochemically Heterogeneous Dopaminergic Neurons in the Substantia Nigra during Spontaneous and Driven Changes in Brain State
J. Neurosci.,
March 4, 2009;
29(9):
2915 - 2925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Matsuda, T. Furuta, K. C. Nakamura, H. Hioki, F. Fujiyama, R. Arai, and T. Kaneko
Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum
J. Neurosci.,
January 14, 2009;
29(2):
444 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Passante, N. Gaspard, M. Degraeve, J. Frisen, K. Kullander, V. De Maertelaer, and P. Vanderhaeghen
Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum
Development,
October 1, 2008;
135(19):
3281 - 3290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Bordia, S. R. Grady, J. M. McIntosh, and M. Quik
Nigrostriatal Damage Preferentially Decreases a Subpopulation of {alpha}6beta2* nAChRs in Mouse, Monkey, and Parkinson's Disease Striatum
Mol. Pharmacol.,
July 1, 2007;
72(1):
52 - 61.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rodriguez, I. Morales, I. Gomez, S. Gonzalez, T. Gonzalez-Hernandez, and J. L. Gonzalez-Mora
Heterogeneous Dopamine Neurochemistry in the Striatum: The Fountain-Drain Matrix
J. Pharmacol. Exp. Ther.,
October 1, 2006;
319(1):
31 - 43.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. C. Baquet, P. C. Bickford, and K. R. Jones
Brain-Derived Neurotrophic Factor Is Required for the Establishment of the Proper Number of Dopaminergic Neurons in the Substantia Nigra Pars Compacta
J. Neurosci.,
June 29, 2005;
25(26):
6251 - 6259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. V. Avshalumov, B. T. Chen, T. Koos, J. M. Tepper, and M. E. Rice
Endogenous Hydrogen Peroxide Regulates the Excitability of Midbrain Dopamine Neurons via ATP-Sensitive Potassium Channels
J. Neurosci.,
April 27, 2005;
25(17):
4222 - 4231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. de Chaldee, M.-C. Gaillard, N. Bizat, J.-M. Buhler, O. Manzoni, J. Bockaert, P. Hantraye, E. Brouillet, and J.-M. Elalouf
Quantitative Assessment of Transcriptome Differences Between Brain Territories
Genome Res.,
July 1, 2003;
13(7):
1646 - 1653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Cragg
Variable Dopamine Release Probability and Short-Term Plasticity between Functional Domains of the Primate Striatum
J. Neurosci.,
May 15, 2003;
23(10):
4378 - 4385.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Cragg, C. J. Hille, and S. A. Greenfield
Functional Domains in Dorsal Striatum of the Nonhuman Primate Are Defined by the Dynamic Behavior of Dopamine
J. Neurosci.,
July 1, 2002;
22(13):
5705 - 5712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Prensa and A. Parent
The Nigrostriatal Pathway in the Rat: A Single-Axon Study of the Relationship between Dorsal and Ventral Tier Nigral Neurons and the Striosome/Matrix Striatal Compartments
J. Neurosci.,
September 15, 2001;
21(18):
7247 - 7260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Garel, F Marin, R Grosschedl, and P Charnay
Ebf1 controls early cell differentiation in the embryonic striatum
Development,
January 12, 1999;
126(23):
5285 - 5294.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. J. Cragg, M. E. Rice, and S. A. Greenfield
Heterogeneity of Electrically Evoked Dopamine Release and Reuptake in Substantia Nigra, Ventral Tegmental Area, and Striatum
J Neurophysiol,
February 1, 1997;
77(2):
863 - 873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
