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 Previous Article
Journal of Neuroscience, Vol 7, 923-929, Copyright © 1987 by Society for Neuroscience
Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system
EM Johnson Jr, M Taniuchi, HB Clark, JE Springer, S Koh, MW Tayrien and R Loy
NGF acts on responsive neurons by binding to specific NGF receptors on
axonal termini, after which a critical biochemical signal is retrogradely
transported to the cell body. The identity of the signal(s) is unknown;
candidates include NGF itself or some other "second messenger." A possible
second messenger is the NGF receptor. As a first step in assessing the
possible role of NGF receptor in the generation of the NGF-dependent
signal, and in understanding the economy of NGF receptor synthesis and
utilization, we determined whether the NGF receptor is retrogradely
transported. Using immunohistochemical staining with a monoclonal antibody
(192-IgG) against rat NGF receptor, we looked for accumulation of NGF
receptor molecules distal (retrograde transport), as well as proximal
(anterograde transport), to sites of axonal ligation or transection. By
10-12 hr in both the ligated sciatic nerve and the lesioned fimbria-
fornix, accumulated NGF receptor was detected proximal and distal to the
ligation/lesion site. The transported receptor presumably was located in
sympathetic and sensory neurons in the sciatic nerve and in forebrain
cholinergic neurons projecting from the medial septum to the hippocampus.
In both anatomical sites, accumulation of NGF receptor on the proximal
(anterograde) side occurred in streams of fine axonal processes, whereas
staining on the distal (retrograde) side occurred in varicose or granular
configurations. These results raise the possibility that the NGF receptor
has a role in the mechanism of NGF beyond the initial binding event at the
plasma membrane of the axonal terminus.
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