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Journal of Neuroscience, Vol 7, 1318-1326, Copyright © 1987 by Society for Neuroscience
Effects of early unilateral blur on the macaque's visual system. I. Behavioral observations
L Kiorpes, RG Boothe, AE Hendrickson, JA Movshon, HM Eggers and MS Gizzi
We raised 8 macaque monkeys with chronic atropinization of one eye
throughout the first 6-10 months after birth. This rearing procedure
produces retinal image blur, with the most pronounced contrast attenuation
occurring at high spatial frequencies. Measurements of contrast sensitivity
were made using behavioral methods in 6 monkeys and evoked potential
methods in 2 monkeys. The results showed that this rearing procedure
produced long-term deficits in the contrast sensitivity and spatial
resolution of the atropinized eye, which were not due to residual losses in
accommodative capacity. There was considerable interanimal variation in the
magnitude of the effects on visual performance. Similar losses in visual
performance are seen in some forms of human amblyopia. Rearing monkeys with
chronic instillation of atropine therefore provides a nonhuman primate
model for studying the underlying neural mechanisms of anisometropic
amblyopia.
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