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Journal of Neuroscience, Vol 7, 1626-1638, Copyright © 1987 by Society for Neuroscience
Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain
MN Lehman, R Silver, WR Gladstone, RM Kahn, M Gibson and EL Bittman
It is well established that overt circadian rhythms are permanently
disrupted following lesions of the hamster hypothalamic suprachiasmatic
nucleus (SCN). In the present study, we show that implantations of brain
grafts containing the fetal SCN reestablish circadian rhythms of locomotor
activity in adult hamsters previously made arrhythmic by SCN lesions. The
restoration of free-running rhythms in conditions of constant darkness is
correlated with the presence in the graft of neuropeptides normally present
in the SCN of unlesioned hamsters, including vasoactive intestinal
polypeptide (VIP), neuropeptide Y (NPY), and vasopressin (VP). In several
recipients, grafts were found to receive retinal input, and appeared to
send efferents into the host brain. Not all functions of the SCN were
reinstated by the graft: animals with restored locomotor rhythms did not
show gonadal regression in the absence of light, and failed to synchronize
(entrain) to light intensities to which SCN-intact animals responded.
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