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Journal of Neuroscience, Vol 7, 1887-1901, Copyright © 1987 by Society for Neuroscience
Glutamate-positive neurons in the somatic sensory cortex of rats and monkeys
F Conti, A Rustioni, P Petrusz and AC Towle
The morphology and laminar distribution of neurons labeled with an
antiserum prepared against glutamic acid (Glu) conjugated to keyhole limpet
hemocyanin have been studied in the somatic sensory cortex of rats and
monkeys. In both species, the vast majority of immunostained neurons are
pyramidal; some nonpyramidal neurons are also present. Positive neurons are
observed in all cortical layers, although variations are found in the
percentage of Glu-positive neurons in the different layers. In rats they
are most numerous in layer V (36%), followed by layer II (33%), layer III
(32%), and layer VI (29%). In layer IV, 13% of all neurons are positive.
Immunoreactive neurons are very sparse in layer I. In monkeys, Glu-positive
neurons represent 51% of all neurons in layer V, 49% in layer III, 40% in
layers II and VI, and 19% in layer IV. No differences are evident in the
laminar distribution of Glu-positive neurons among cytoarchitectonic areas
3a, 3b, 1, and 2. As in rats, Glu-positive neurons are very sparse in layer
I. Since Glu and GABA metabolisms are closely related, double-labeling
experiments were performed in which thin, adjacent paraffin sections were
stained alternately with the anti-Glu serum and with an anti-GABA serum.
The 2 populations are almost completely segregated, even though a small
fraction of neurons (less than 5%) are labeled by the antisera against both
antigens.(ABSTRACT TRUNCATED AT 250 WORDS)
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