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Journal of Neuroscience, Vol 7, 1951-1968, Copyright © 1987 by Society for Neuroscience
The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells
RU Muller and JL Kubie
Using the techniques set out in the preceding paper (Muller et al., 1987),
we investigated the response of place cells to changes in the animal's
environment. The standard apparatus used was a cylinder, 76 cm in diameter,
with walls 51 cm high. The interior was uniformly gray except for a white
cue card that ran the full height of the wall and occupied 100 degrees of
arc. The floor of the apparatus presented no obstacles to the animal's
motions. Each of these major features of the apparatus was varied while the
others were held constant. One set of manipulations involved the cue card.
Rotating the cue card produced equal rotations of the firing fields of
single cells. Changing the width of the card did not affect the size,
shape, or radial position of firing fields, although sometimes the field
rotated to a modest extent. Removing the cue card altogether also left the
size, shape, and radial positions of firing fields unchanged, but caused
fields to rotate to unpredictable angular positions. The second set of
manipulations dealt with the size and shape of the apparatus wall. When the
standard (small) cylinder was scaled up in diameter and height by a factor
of 2, the firing fields of 36% of the cells observed in both cylinders also
scaled, in the sense that the field stayed at the same angular position and
at the same relative radial position. Of the cells recorded in both
cylinders, 52% showed very different firing patterns in one cylinder than
in the other. The remaining 12% of the cells were virtually silent in both
cylinders. Similar results were obtained when individual cells were
recorded in both a small and a large rectangular enclosure. By contrast,
when the apparatus floor plan was changed from circular to rectangular, the
firing pattern of a cell in an apparatus of one shape could not be
predicted from a knowledge of the firing pattern in the other shape. The
final manipulations involved placing vertical barriers into the otherwise
unobstructed floor of the small cylinder. When an opaque barrier was set up
to bisect a previously recorded firing field, in almost all cases the
firing field was nearly abolished. This was true even though the barrier
occupied only a small fraction of the firing field area. A transparent
barrier was effective as the opaque barrier in attenuating firing fields.
The lead base used to anchor the vertical barriers did not affect place
cell firing.(ABSTRACT TRUNCATED AT 400 WORDS)
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