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Journal of Neuroscience, Vol 7, 2113-2128, Copyright © 1987 by Society for Neuroscience
Multiple mechanisms of bursting in a conditional bursting neuron
RM Harris-Warrick and RE Flamm
The anterior burster (AB) neuron in the stomatogastric ganglion of the
spiny lobster, Panulirus interruptus, is a conditional burster in the
pyloric motor circuit. Bath application of the monoamines dopamine,
serotonin, and octopamine induces rhythmic bursting pacemaker potentials in
a silent, synaptically isolated AB cell. However, each amine produces a
unique and characteristic burst shape, resulting from different ionic
dependences of the burst mechanisms. Bursting induced by serotonin or
octopamine is critically dependent upon sodium entry through
tetrodotoxin-sensitive channels; dopamine-induced bursting is not
TTX-sensitive. Dopamine-induced bursting is abolished when extracellular
calcium is reduced to 25% of normal; serotonin- and octopamine-induced
bursts continue in this saline, although they are abolished in salines with
calcium reduced to 10% or less of normal. Quantitative differences between
the amines are also seen in the tetraethylammonium (TEA) sensitivity of the
burst amplitude and in the dependence of the interburst hyperpolarization
on extracellular potassium. These experiments demonstrate that there are
both quantitative and qualitative differences in the ionic currents
underlying every phase of the bursts induced by the 3 amines. Thus, a
single neuron can burst via more than one ionic mechanism.
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