 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 7, 2745-2755, Copyright © 1987 by Society for Neuroscience
N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey
P Wallen and S Grillner
Bath application of N-methyl-aspartate induces fictive locomotor activity
in the isolated spinal cord preparation of the lamprey, as well as
TTX-resistant membrane potential oscillations in many individual neurons.
This inherent oscillatory activity is shown to depend on a specific
activation of N-methyl-D-aspartate (NMDA) receptors. This activation
initiates voltage-dependent, magnesium- requiring membrane potential
bistability, presumably due to a development of a region of negative slope
conductance in the current- voltage relation of the neuron. When sodium
ions were removed from the bathing solution, oscillations disappeared, and
the membrane potential was maintained at a hyperpolarized level, suggesting
that the depolarizing current during the oscillatory cycle is mainly
carried by sodium ions. Replacing Ca2+ with Ba2+ also leads to a cessation
of oscillatory activity, with the membrane potential remaining at the more
depolarized level. This indicates an involvement of a Ca2+-dependent K+
current during the repolarization phase. These findings, together with the
voltage dependence, can account for the main characteristics of the NMDA
receptor-induced, TTX-resistant membrane potential oscillations. This
oscillatory behavior has been demonstrated in motoneurons and in several
interneurons including CC interneurons but has not been found in edge
cells, dorsal cells, or lateral interneurons. The possibility that inherent
oscillatory membrane properties may contribute to the activity pattern
during fictive locomotion was investigated in experiments with
intracellular current injection in the absence of TTX. The stimulation
effects obtained required the presence of magnesium ions and were analogous
to the stimulation effects seen during oscillations after TTX blockade.
Together with similarities in, for instance, frequency and amplitude
between the locomotor oscillatory activity and the TTX-resistant
oscillations, the results are compatible with an involvement of inherent,
oscillatory membrane properties during fictive locomotion in the lamprey
spinal cord.
This article has been cited by other articles:
|
|
|
|
 
O. Ibanez-Sandoval, L. Carrillo-Reid, E. Galarraga, D. Tapia, E. Mendoza, J. C. Gomora, J. Aceves, and J. Bargas
Bursting in Substantia Nigra Pars Reticulata Neurons In Vitro: Possible Relevance for Parkinson Disease
J Neurophysiol,
October 1, 2007;
98(4):
2311 - 2323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Perez, R. H. Hill, and S. Grillner
Endogenous Tachykinin Release Contributes to the Locomotor Activity in Lamprey
J Neurophysiol,
May 1, 2007;
97(5):
3331 - 3339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Huss, A. Lansner, P. Wallen, A. El Manira, S. Grillner, and J. H. Kotaleski
Roles of Ionic Currents in Lamprey CPG Neurons: A Modeling Study
J Neurophysiol,
April 1, 2007;
97(4):
2696 - 2711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Rabbah and F. Nadim
Distinct Synaptic Dynamics of Heterogeneous Pacemaker Neurons in an Oscillatory Network
J Neurophysiol,
March 1, 2007;
97(3):
2239 - 2253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Serrano and M. W. Miller
Conditional Rhythmicity and Synchrony in a Bilateral Pair of Bursting Motor Neurons in Aplysia
J Neurophysiol,
October 1, 2006;
96(4):
2056 - 2071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Guertin and J. Hounsgaard
Conditional Intrinsic Voltage Oscillations in Mature Vertebrate Neurons Undergo Specific Changes in Culture
J Neurophysiol,
March 1, 2006;
95(3):
2024 - 2027.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. C. Cowley, E. Zaporozhets, J. N. MacLean, and B. J. Schmidt
Is NMDA Receptor Activation Essential for the Production of Locomotor-Like Activity in the Neonatal Rat Spinal Cord?
J Neurophysiol,
December 1, 2005;
94(6):
3805 - 3814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Schwartz, T. Gerachshenko, and S. Alford
5-HT Prolongs Ventral Root Bursting Via Presynaptic Inhibition of Synaptic Activity During Fictive Locomotion in Lamprey
J Neurophysiol,
February 1, 2005;
93(2):
980 - 988.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. W. Cui, L. Saint-Amant, and J. Y. Kuwada
shocked Gene Is Required for the Function of a Premotor Network in the Zebrafish CNS
J Neurophysiol,
November 1, 2004;
92(5):
2898 - 2908.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Viana Di Prisco and S. Alford
Quantitative Investigation of Calcium Signals for Locomotor Pattern Generation in the Lamprey Spinal Cord
J Neurophysiol,
September 1, 2004;
92(3):
1796 - 1806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Giroux, C. Chau, H. Barbeau, T. A. Reader, and S. Rossignol
Effects of Intrathecal Glutamatergic Drugs on Locomotion. II. NMDA and AP-5 in Intact and Late Spinal Cats
J Neurophysiol,
August 1, 2003;
90(2):
1027 - 1045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Alford, E. Schwartz, and G. V. Di Prisco
The Pharmacology of Vertebrate Spinal Central Pattern Generators
Neuroscientist,
June 1, 2003;
9(3):
217 - 228.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Cangiano and S. Grillner
Fast and Slow Locomotor Burst Generation in the Hemispinal Cord of the Lamprey
J Neurophysiol,
June 1, 2003;
89(6):
2931 - 2942.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Chau, N. Giroux, H. Barbeau, L. Jordan, and S. Rossignol
Effects of Intrathecal Glutamatergic Drugs on Locomotion I. NMDA in Short-Term Spinal Cats
J Neurophysiol,
December 1, 2002;
88(6):
3032 - 3045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Martin
Changes in Electrophysiological Properties of Lamprey Spinal Motoneurons During Fictive Swimming
J Neurophysiol,
November 1, 2002;
88(5):
2463 - 2476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Takahashi and S. Alford
The Requirement of Presynaptic Metabotropic Glutamate Receptors for the Maintenance of Locomotion
J. Neurosci.,
May 1, 2002;
22(9):
3692 - 3699.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-F. Hsiao, N. Wu, M. S. Levine, and S. H. Chandler
Development and Serotonergic Modulation of NMDA Bursting in Rat Trigeminal Motoneurons
J Neurophysiol,
March 1, 2002;
87(3):
1318 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. W. Keefer, A. Gramowski, and G. W. Gross
NMDA Receptor-Dependent Periodic Oscillations in Cultured Spinal Cord Networks
J Neurophysiol,
December 1, 2001;
86(6):
3030 - 3042.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. MacLean and B. J. Schmidt
Voltage-Sensitivity of Motoneuron NMDA Receptor Channels Is Modulated by Serotonin in the Neonatal Rat Spinal Cord
J Neurophysiol,
September 1, 2001;
86(3):
1131 - 1138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Jean
Brain Stem Control of Swallowing: Neuronal Network and Cellular Mechanisms
Physiol Rev,
April 1, 2001;
81(2):
929 - 969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Buschges, M. A. Wikstrom, S. Grillner, and A. El Manira
Roles of High-Voltage-Activated Calcium Channel Subtypes in a Vertebrate Spinal Locomotor Network
J Neurophysiol,
December 1, 2000;
84(6):
2758 - 2766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Krieger, J. Hellgren-Kotaleski, P. Kettunen, and A. J. El Manira
Interaction between Metabotropic and Ionotropic Glutamate Receptors Regulates Neuronal Network Activity
J. Neurosci.,
July 15, 2000;
20(14):
5382 - 5391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Saint-Amant and P. Drapeau
Motoneuron Activity Patterns Related to the Earliest Behavior of the Zebrafish Embryo
J. Neurosci.,
June 1, 2000;
20(11):
3964 - 3972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. L. Stark and D. J. Perkel
Two-Stage, Input-Specific Synaptic Maturation in a Nucleus Essential for Vocal Production in the Zebra Finch
J. Neurosci.,
October 15, 1999;
19(20):
9107 - 9116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Prime, Y. Pichon, and L. E. Moore
N-Methyl-D-Aspartate-Induced Oscillations in Whole Cell Clamped Neurons From the Isolated Spinal Cord of Xenopus laevis Embryos
J Neurophysiol,
August 1, 1999;
82(2):
1069 - 1073.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Buchanan
Commissural Interneurons in Rhythm Generation and Intersegmental Coupling in the Lamprey Spinal Cord
J Neurophysiol,
May 1, 1999;
81(5):
2037 - 2045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. del Negro, C.-F. Hsiao, and S. H. Chandler
Outward Currents Influencing Bursting Dynamics in Guinea Pig Trigeminal Motoneurons
J Neurophysiol,
April 1, 1999;
81(4):
1478 - 1485.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tegner and S. Grillner
Interactive Effects of the GABABergic Modulation of Calcium Channels and Calcium-Dependent Potassium Channels in Lamprey
J Neurophysiol,
March 1, 1999;
81(3):
1318 - 1329.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Guertin and J. Hounsgaard
NMDA-Induced Intrinsic Voltage Oscillations Depend on L-Type Calcium Channels in Spinal Motoneurons of Adult Turtles
J Neurophysiol,
December 1, 1998;
80(6):
3380 - 3382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Parker, W. Zhang, and S. Grillner
Substance P Modulates NMDA Responses and Causes Long-Term Protein Synthesis-Dependent Modulation of the Lamprey Locomotor Network
J. Neurosci.,
June 15, 1998;
18(12):
4800 - 4813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-F. Hsiao, C. A. D. Negro, P. R. Trueblood, and S. H. Chandler
Ionic Basis for Serotonin-Induced Bistable Membrane Properties in Guinea Pig Trigeminal Motoneurons
J Neurophysiol,
June 1, 1998;
79(6):
2847 - 2856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. V. Di Prisco, E. Pearlstein, R. Robitaille, and R. Dubuc
Role of Sensory-Evoked NMDA Plateau Potentials in the Initiation of Locomotion
Science,
November 7, 1997;
278(5340):
1122 - 1125.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. D. McClellan and A. Hagevik
Descending Control of Turning Locomotor Activity in Larval Lamprey: Neurophysiology and Computer Modeling
J Neurophysiol,
July 1, 1997;
78(1):
214 - 228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tegner, J. Hellgren-Kotaleski, A. Lansner, and S. Grillner
Low-Voltage-Activated Calcium Channels in the Lamprey Locomotor Network: Simulation and Experiment
J Neurophysiol,
April 1, 1997;
77(4):
1795 - 1812.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-S. Rioult-Pedotti
Intrinsic NMDA-Induced Oscillations in Motoneurons of an Adult Vertebrate Spinal Cord Are Masked by Inhibition
J Neurophysiol,
February 1, 1997;
77(2):
717 - 730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Kemnitz
Dopaminergic Modulation of Spinal Neurons and Synaptic Potentials in the Lamprey Spinal Cord
J Neurophysiol,
January 1, 1997;
77(1):
289 - 298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Ekeberg, S. Grillner, and A. Lansner
The Neural Control of Fish Swimming Studied Through Numerical Simulations
Adaptive Behavior,
March 1, 1995;
3(4):
363 - 384.
[Abstract]
[PDF]
|
|
|
|
