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Journal of Neuroscience, Vol 7, 2837-2843, Copyright © 1987 by Society for Neuroscience
Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli
ED Abercrombie and BL Jacobs
The present experiment was designed to explore the stress-relatedness of
activity in noradrenergic neurons of the locus coeruleus (LC) of behaving
cats. A stressor was defined as a stimulus that elicited a significant
sympathoadrenal activation as measured by plasma norepinephrine level and
heart rate. According to this definition, exposure to 15 min of 100 dB
white noise or 15 min of restraint was stressful in cats. In contrast,
exposure to inaccessible rats for 15 min was behaviorally activating but
nonstressful. The single-unit activity of noradrenergic neurons in the LC
of behaving cats was examined under these conditions. The stressful stimuli
elicited a significant increase in LC neuronal activity for the entire 15
min stressor duration, whereas the behaviorally activating but nonstressful
stimulus elicited no significant change in the activity of these neurons.
These results provide evidence that behavioral activation per se is not
sufficient to evoke a tonic activation of these neurons. Rather, these data
support the hypothesis that the LC is involved in the CNS response to
stress and provide additional evidence that the activity of LC
noradrenergic neurons increases in association with sympathoadrenal
activation.
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