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Journal of Neuroscience, Vol 7, 2894-2909, Copyright © 1987 by Society for Neuroscience
Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat
M Vidal-Sanz, GM Bray, MP Villegas-Perez, S Thanos and AJ Aguayo
In adult rats, one optic nerve was transected and replaced by a 4 cm
segment of autologous peripheral nerve (PN) that linked one eye and the
superior colliculus (SC) along a predominantly extracranial course.
Retrograde and orthograde studies with the tracers HRP or rhodamine-B-
isothiocyanate (RITC), as well as immunocytochemical neuronal labels,
indicated the following: (1) Regenerating axons from the axotomized retinal
ganglion cells extended along the entire PN grafts, covering a distance
nearly twice that of the normal retinotectal projection of intact rats. (2)
Some of these axons penetrated the SC and formed terminal arborizations up
to 500 microns from the end of the graft. (3) By electron microscopy, the
arborizations of these regenerated axons in the SC were seen as small
HRP-labeled axonal profiles that contacted neuronal processes in the SC;
some of these contacts showed pre- and postsynaptic membrane
specializations. These findings indicate that injured retinal ganglion
cells in the adult rat are not only able to regrow lengthy axons, but may
also form synapses in the SC.
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