 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 8, 242-255, Copyright © 1988 by Society for Neuroscience
Identification of the neuropeptide transmitter proctolin in Drosophila larvae: characterization of muscle fiber-specific neuromuscular endings
MS Anderson, ME Halpern and H Keshishian
Biology Department, Yale University, New Haven, Connecticut 06511.
The cellular localization of the peptide neurotransmitter proctolin was
determined for larvae of the fruitfly Drosophila melanogaster. Proctolin
was recovered from the CNS, hindgut, and segmental bodywall using
reverse-phase HPLC, and characterized by bioassay, immunoassay, and
enzymatic analysis. A small, stereotyped population of proctolin-
immunoreactive neurons was found in the larval CNS. Several of the
identified neurons may be efferents. In the periphery, proctolin-
immunoreactive neuromuscular endings were identified on both visceral and
skeletal muscle fibers. On the hindgut, the neuropeptide is associated with
endings on intrinsic circular muscle fibers. We propose that the hindgut
muscle fibers are innervated by central neurons homologous to previously
described proctolinergic efferents of grasshoppers. The segmental bodywall
innervation consists of a pattern of segment-specific junctions on several
singly identifiable muscle fibers. While it is generally accepted that
Drosophila muscle fibers are innervated by glutamatergic motoneurons, our
data indicate that a specialized subset of muscle fibers are also
innervated by peptidergic efferents.
This article has been cited by other articles:
|
|
|
|
 
I. Miguel-Aliaga and S. Thor
Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity
Development,
December 15, 2004;
131(24):
6093 - 6105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Choi, D. Park, and L. C. Griffith
Electrophysiological and Morphological Characterization of Identified Motor Neurons in the Drosophila Third Instar Larva Central Nervous System
J Neurophysiol,
May 1, 2004;
91(5):
2353 - 2365.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. C. Johnson, S. F. Garczynski, D. Park, J. W. Crim, D. R. Nassel, and P. H. Taghert
Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster
PNAS,
May 13, 2003;
100(10):
6198 - 6203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Zelhof, H. Bao, R. W. Hardy, A. Razzaq, B. Zhang, and C. Q. Doe
Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis
Development,
December 15, 2001;
128(24):
5005 - 5015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Hewes and P. H. Taghert
Neuropeptides and Neuropeptide Receptors in the Drosophila melanogaster Genome
Genome Res.,
June 1, 2001;
11(6):
1126 - 1142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Schmid, A Chiba, and C. Doe
Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets
Development,
January 11, 1999;
126(21):
4653 - 4689.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. S. Hewes, E. C Snowdeal III, M. Saitoe, and P. H. Taghert
Functional Redundancy of FMRFamide-Related Peptides at the Drosophila Larval Neuromuscular Junction
J. Neurosci.,
September 15, 1998;
18(18):
7138 - 7151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yoshihara, M. B. Rheuben, and Y. Kidokoro
Transition from Growth Cone to Functional Motor Nerve Terminal in Drosophila Embryos
J. Neurosci.,
November 1, 1997;
17(21):
8408 - 8426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Martinez-Padron and A. Ferrus
Presynaptic Recordings from Drosophila: Correlatin of Macroscopic and Single-Channel K+ Currents
J. Neurosci.,
May 15, 1997;
17(10):
3412 - 3424.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Hoshino, E Suzuki, Y Nabeshima, and C Hama
Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila
Development,
January 2, 1996;
122(2):
589 - 597.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y Zhong and C. Wu
Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade
Science,
January 11, 1991;
251(4990):
198 - 201.
[Abstract]
[PDF]
|
|
|
|
