QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tobin, A. B. Articles by Osborne, N. N. Search for Related Content PubMed PubMed Citation Articles by Tobin, A. B. Articles by Osborne, N. N.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 8, 3713-3721, Copyright © 1988 by Society for Neuroscience

ARTICLE

Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit

AB Tobin, W Unger and NN Osborne
Nuffield Laboratory of Ophthalmology, Oxford University, United Kingdom.

The rabbit iris-ciliary body contains 78 +/- 6 ng/gm serotonin (5-HT) while the amine content in the aqueous humor is less than 0.01 ng/100 microliter. The low levels of endogenous 5-HT in the iris-ciliary body could not be directly detected by immunocytochemistry. However, pretreatment in vivo and in vitro with L-tryptophan and pargyline resulted in the localization of a sparse population of 5-HT fibers. These fibers could not be studied by exposing the tissue to exogenous 5- HT since the amine was taken up by noradrenergic fibers as well. This was confirmed in studies involving superior cervical ganglionectomy. It is concluded that 5-HT is taken up by both serotonergic and adrenergic fibers of the iris-ciliary body. In the presence of lithium, 5-HT stimulated an increase in the 3H-inositol phosphate accumulation in a dose-dependent manner in tissue where the phosphoinositide pool was labeled with 3H-inositol. A variety of agonists and antagonists were used to show that the 5-HT response is mediated, at least partly, by 5- HT2 receptors. The 5-HT-mediated effect on inositol phosphates is unaffected by superior cervical ganglionectomy. The effect of noradrenaline, which also stimulates inositol phosphate accumulation (but via alpha 1-adrenergic receptors in the iris-ciliary body), was elevated following superior cervical ganglionectomy.

This article has been cited by other articles:

				R. S Kumar, J. Grigg, and A. C Farinelli Ecstasy induced acute bilateral angle closure and transient myopia Br. J. Ophthalmol., May 1, 2007; 91(5): 693 - 695. [Full Text] [PDF]

				N. A. Sharif, C. R. Kelly, and M. McLaughlin Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT2A) Receptors: Role in IOP Reduction. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 4001 - 4010. [Abstract] [Full Text] [PDF]

				J. Y. Crider, G. W. Williams, C. D. Drace, P. Katoli, M. Senchyna, and N. A. Sharif Pharmacological Characterization of a Serotonin Receptor (5-HT7) Stimulating cAMP Production in Human Corneal Epithelial Cells Invest. Ophthalmol. Vis. Sci., November 1, 2003; 44(11): 4837 - 4844. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help