WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience The New Axio Examiner
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Turski, L.
Right arrow Articles by Turski, W. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Turski, L.
Right arrow Articles by Turski, W. A.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 8, 4027-4037, Copyright © 1988 by Society for Neuroscience

ARTICLE

Dopamine-sensitive anticonvulsant site in the rat striatum

L Turski, EA Cavalheiro, ZA Bortolotto, C Ikonomidou-Turski, Z Kleinrok and WA Turski
Department of Pharmacology, Medical School, Lublin, Poland.

The basal ganglia are involved in the organization of movement and function in the initiation and expression of generalized and limbic seizures. Dopamine is the principal neurotransmitter of the mesencephalic efferent pathways terminating in the mammalian striatum. No function has been ascribed to mesostriatal dopamine in the control of seizure spread in the brain. This work presents evidence that bilateral application of picomole amounts of apomorphine (a dopamine agonist) into the striatum confers protection against seizures produced by pilocarpine (a cholinergic agonist) in rats. The anticonvulsant effect of apomorphine is topographically confined to the caudate- putamen, nucleus accumbens, and olfactory tubercle. Bilateral application of nanomolar amounts of haloperidol (a dopamine antagonist) into the caudate-putamen or systemic application of haloperidol both lower the threshold for pilocarpine-induced seizures. Local application of an excitatory amino acid N-methyl-D-aspartate, into the substantia nigra pars compacta, ventral tegmental area, or retrorubral area, sites of origin of mesostriatal dopaminergic pathways, protects rats against seizures produced by pilocarpine. These results suggest that dopaminergic transmission in the striatum may be operative in complex neuronal networks modulating the seizure threshold.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. Bandyopadhyay, C. Gonzalez-Islas, and J. J. Hablitz
Dopamine Enhances Spatiotemporal Spread of Activity in Rat Prefrontal Cortex
J Neurophysiol, February 1, 2005; 93(2): 864 - 872.
[Abstract] [Full Text] [PDF]

Home page
 Palliat MedHome page
I. N Back
Terminal restlessness in patients with advanced malignant disease
Palliative Medicine, October 1, 1992; 6(4): 293 - 298.
[Abstract] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-