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Journal of Neuroscience, Vol 8, 4340-4348, Copyright © 1988 by Society for Neuroscience
Comparison of effects of D-1 and D-2 dopamine receptor agonists on neurons in the rat caudate putamen: an electrophysiological study
XT Hu and RY Wang
Department of Psychiatry and Behavioral Sciences, State University of New York, Stony Brook 11794.
Extracellular single-unit recording and microiontophoretic techniques were
used to characterize the pharmacological properties of dopamine (DA)
receptor subtypes within the rat caudate putamen (CPu), a striatal
structure that receives a dense innervation from DA neurons originating
from the substantia nigra pars compacta (A9 DA neurons). Similar to the
action of DA, the DA D-1 receptor agonist (+)SKF-38393 generally
potentiated the activation produced by glutamate (GLU) at low ejection
currents (less than or equal to 5 nA); at higher ejection currents, it
depressed 97% of the CPu neurons tested. By contrast, the D-2 receptor
agonist LY-171555 (quinpirole) was much less effective in affecting the
firing rate of CPu cells. The selective D-1 antagonist SCH-23390,
administered either intravenously or iontophoretically, completely blocked
the (+)SKF-38393-induced effects on CPu cells but failed to change the
depressant effects produced by either quinpirole or 5-HT. On the other
hand, the selective D-2 antagonist I-sulpiride, blocked the effects induced
by quinpirole but not (+)SKF-38393. These observations suggest that the D-1
and D-2 DA receptor agonists elicit their effects via distinct DA receptor
subtypes. A comparison of these results with our previous results obtained
from the nucleus accumbens (NAc) indicates that NAc cells are more
responsive to DA D-2 agonist, whereas CPu cells are more sensitive to D-1
agonist. Therefore, D-1 receptors in the CPu may have a critical role in
mediating the effect produced by DA.(ABSTRACT TRUNCATED AT 400 WORDS)
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