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Journal of Neuroscience, Vol 8, 4513-4530, Copyright © 1988 by Society for Neuroscience
Retinotopic organization of the developing retinotectal projection in the zebrafish embryo
CA Stuermer
Friedrich-Miescher-Laboratorium der Max-Planck-Gesellschaft, Tubingen, Federal Republic of Germany.
Developing retinal axons in the zebrafish embryo were stained with HRP or
with the fluorescent dyes dil and diO to study the formation of the
retinotectal projection. Retinal axons leave the eye at 34-36 hr
postfertilization (PF), invade the tectum at 46-48 hr PF, and innervate the
tectal neuropil at 70-72 hr PF. Dorsal and ventral axons occupy separate
aspects of the optic nerve and tract and pass into their retinotopically
appropriate ventral and dorsal hemitectum, respectively. Nasal and temporal
axons are segregated in the nerve, mixed in the tract, and are coextensive
over the rostral half of tectum until 56 hr PF. They then segregate again,
due to the progression of nasal axons into the open caudal tectum. Thus, at
70-72 hr PF, dorsal and ventral as well as temporal and nasal axons occupy
their retinotopically appropriate tectal quadrants. After ablation of the
temporal retina prior to the time of axonal outgrowth, the nasal axons
bypass the vacant rostral tectum to terminate in the caudal tectal half.
Temporal axons in the absence of nasal axons remain restricted to their
appropriate rostral tectal half, suggesting that nasal and temporal axons
possess a preference for their retinotopically appropriate tectal domains.
Measurements of individual terminal arbors and the tectal areas in embryos
and in adult zebrafish showed that individual arbors are large with respect
to the embryonic tectum but are about 14-15 times smaller than in the
adult. However, the proportion of tectum covered by embryonic arbors is
about 7 times larger than in the adult, suggesting that a higher precision
of the adult projection is achieved as a result of a greater enlargement of
the tectum than of the arbors.
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