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Journal of Neuroscience, Vol 8, 4653-4661, Copyright © 1988 by Society for Neuroscience
A unique membrane protein is expressed on early developing limbic system axons and cortical targets
HL Horton and P Levitt
Department of Anatomy, Medical College of Pennsylvania, Philadelphia 19129.
The limbic system-associated membrane protein (LAMP) is a 64 kDa protein
that, in the adult brain, is present in cortical and subcortical regions
comprising the limbic system (Levitt, 1984). The developmental expression
of LAMP was studied in fetal rat brains to determine the specific patterns
of distribution and the cellular elements that exhibit LAMP
immunoreactivity. Light microscopic immunocytochemical analysis revealed
that LAMP is expressed on neurons and their growing axons early in fetal
development, at a time coincident with pathway formation and
differentiation of limbic system nuclei. In the forebrain, where limbic
system structures are heavily concentrated, immunoreactivity appears on
subpopulations of axons in a temporal sequence that correlates with the
time of formation of pathways carrying limbic system axons. Thus, staining
is evident first at embryonic day (E) 15 on fibers within the internal
capsule coursing from the diencephalon to cortex. LAMP immunoreactivity
appears over the next 3 d in the anterior commissure, fornix, and corpus
callosum. Ultrastructural immunocytochemical analysis reveals dense surface
staining of fascicles of developing axons and growth cones. The axonal
staining is transient, disappearing during the second postnatal week of
development. In cerebral cortex, cells in presumptive limbic cortical
regions such as lateral perirhinal sulcal cortex and prefrontal cortex are
LAMP immunoreactive from the inception of the cortical plate. These
cortical regions are clearly delineated from surrounding unstained
nonlimbic areas as early as E15. Thus, LAMP expression in the cortex may
represent one of the earliest markers of specific cytoarchitectonic
areas.(ABSTRACT TRUNCATED AT 250 WORDS)
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