WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Join the Society for Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giulian, D.
Right arrow Articles by Ingeman, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giulian, D.
Right arrow Articles by Ingeman, J. E.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 8, 4707-4717, Copyright © 1988 by Society for Neuroscience

ARTICLE

Colony-stimulating factors as promoters of ameboid microglia

D Giulian and JE Ingeman
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.

Immunomodulators were tested for their ability to stimulate proliferation and biologic activity of ameboid microglia. Only the colony-stimulating factors (CSFs), multipotential-CSF (multi-CSF) and granulocyte/macrophage-CSF (GM-CSF), were potent mitogens for microglia. Other immunomodulators, including interleukin-1, interleukin- 2, interferon gamma, tumor necrosis factor, or granulocyte-CSF (G-CSF), had no effect upon microglial growth in vitro. Multi-CSF or GM-CSF were also observed to induce more rapid phagocytosis of polystyrene microspheres by cultured ameboid cells. In order to determine which immunomodulators alter brain inflammatory responses in vivo, we infused recombinant forms of GM-CSF, multi-CSF, macrophage-CSF, or G-CSF into the cerebral cortex of rats. Within 48 hr after infusion multi-CSF or GM-CSF stimulated the appearance of large numbers of mononuclear phagocytes at the site of injection. These same factors also accelerated the clearance of polystyrene microspheres from the brain. Our observations indicate that certain classes of immunomodulators which are mitogens and activators of ameboid microglia in vitro amplify the inflammatory response of the CNS in vivo by action upon intrinsic brain mononuclear phagocytes.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
T. M. Kauppinen, Y. Higashi, S. W. Suh, C. Escartin, K. Nagasawa, and R. A. Swanson
Zinc Triggers Microglial Activation
J. Neurosci., May 28, 2008; 28(22): 5827 - 5835.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. K. Mander, A. Jekabsone, and G. C. Brown
Microglia Proliferation Is Regulated by Hydrogen Peroxide from NADPH Oxidase
J. Immunol., January 15, 2006; 176(2): 1046 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-S. Suh, M.-O. Kim, and S. C. Lee
Inhibition of Granulocyte-Macrophage Colony-Stimulating Factor Signaling and Microglial Proliferation by Anti-CD45RO: Role of Hck Tyrosine Kinase and Phosphatidylinositol 3-Kinase/Akt
J. Immunol., March 1, 2005; 174(5): 2712 - 2719.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. S. Ousman and S. David
MIP-1{alpha}, MCP-1, GM-CSF, and TNF-{alpha} Control the Immune Cell Response That Mediates Rapid Phagocytosis of Myelin from the Adult Mouse Spinal Cord
J. Neurosci., July 1, 2001; 21(13): 4649 - 4656.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Tian, V. Litvak, and S. Lev
Cerebral Ischemia and Seizures Induce Tyrosine Phosphorylation of PYK2 in Neurons and Microglial Cells
J. Neurosci., September 1, 2000; 20(17): 6478 - 6487.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Matsubara, G. Pararajasegaram, G.-S. Wu, and N. A. Rao
Retinal Microglia Differentially Express Phenotypic Markers of Antigen-Presenting Cells In Vitro
Invest. Ophthalmol. Vis. Sci., December 1, 1999; 40(13): 3186 - 3193.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. M. Murphy Jr., L. Yang, and B. Cordell
Macrophage Colony-stimulating Factor Augments beta -Amyloid-induced Interleukin-1, Interleukin-6, and Nitric Oxide Production by Microglial Cells
J. Biol. Chem., August 14, 1998; 273(33): 20967 - 20971.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Eder
Ion channels in microglia (brain macrophages)
Am J Physiol Cell Physiol, August 1, 1998; 275(2): C327 - C342.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Dobbertin, P. Schmid, M. Gelman, J. Glowinski, and M. Mallat
Neurons Promote Macrophage Proliferation by Producing Transforming Growth Factor-beta 2
J. Neurosci., July 15, 1997; 17(14): 5305 - 5315.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Mönning, R. Sandbrink, A. Weidemann, R. B. Banati, C. L. Masters, and K. Beyreuther
Extracellular Matrix Influences the Biogenesis of Amyloid Precursor Protein in Microglial Cells
J. Biol. Chem., March 31, 1995; 270(13): 7104 - 7110.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. Watkins, H. Dorn, W. Kelly, R. Armstrong, B. Potts, F Michaels, C. Kufta, and M Dubois-Dalcq
Specific tropism of HIV-1 for microglial cells in primary human brain cultures
Science, August 3, 1990; 249(4968): 549 - 553.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
O. M. Mitrasinovic, G. V. Perez, F. Zhao, Y. L. Lee, C. Poon, and G. M. Murphy Jr.
Overexpression of Macrophage Colony-stimulating Factor Receptor on Microglial Cells Induces an Inflammatory Response
J. Biol. Chem., August 3, 2001; 276(32): 30142 - 30149.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-