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Next Article 
Journal of Neuroscience, Vol 8, 369-382, Copyright © 1988 by Society for Neuroscience
Distribution of protein kinase C-like immunoreactive neurons in rat brain
N Saito, U Kikkawa, Y Nishizuka and C Tanaka
Department of Pharmacology, Kobe University School of Medicine, Japan.
Distribution of protein kinase C in the CNS of rat is presented based on
immunohistochemical analysis with monoclonal antibodies against this
protein kinase. Protein kinase C-like immunoreactivity was discretely
localized and associated with neurons. Most, if not all, glial cells were
not significantly stained. The greatest density of the immunoreactive
material was seen in the following regions: the olfactory bulb (external
plexiform layer), olfactory tuberculum, anterior olfactory nucleus,
cerebral cortex (layers I and IV), pyriform cortex, hippocampus (strata
radiatum and oriens), amygdaloid complex (central and basolateral nuclei),
cerebellar cortex (molecular layer), dorsal cochlear nucleus, nucleus
spinal tract of the trigeminal nerve, and dorsal horn of the spinal cord
(substantia gelatinosa). Image analysis revealed that the regional
distribution of the protein kinase C-like immunoreaction generally agreed
with that of phorbol ester- binding sites. Immunoreactive perikarya were
found in the following areas: the cerebral cortex (layers V and VI),
caudate putamen, hippocampus, thalamus, amygdaloid complex, medial and
lateral geniculate nucleus, superior colliculus, cerebellar cortex, nucleus
spinal tract of the trigeminal nerve, dorsal cochlear nucleus, and dorsal
horn of the spinal cord. Intense protein kinase C-like immunoreactivity in
the neuron was observed both in the membrane and cytoplasm of the
perikarya, dendrites, axons, and axon terminals, while weak immunoreaction
was seen in the nuclei but almost never in the nucleoles. A map of protein
kinase C-containing neurons was constructed. Such an uneven distribution in
the brain suggests that this enzyme may play roles in controlling neuronal
function in the areas noted.
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