QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Sutton, J. K. Articles by Brunso-Bechtold, J. K. Search for Related Content PubMed PubMed Citation Articles by Sutton, J. K. Articles by Brunso-Bechtold, J. K.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 8, 435-444, Copyright © 1988 by Society for Neuroscience

ARTICLE

The roles of specificity and competition in the formation of a laminated colliculogeniculate projection

JK Sutton and JK Brunso-Bechtold
Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

In the present study, we examined the colliculogeniculate projection in normal adult tree shrews and in adults that were bilaterally enucleated at birth. We injected lectin-conjugated HRP into superficial superior colliculus and then mapped the pattern of anterogradely transported enzyme in the ipsilateral dLGN. In normal adult tree shrews, the results confirm that the colliculogeniculate projection is laminated and terminates predominantly in small-celled layers 3 and 6 and in the interlaminar space between layers 4 and 5 (Fitzpatrick et al., 1980); we report an additional sparse projection to layer 4. In bilaterally enucleated animals, the colliculogeniculate projection is unlaminated and tends to terminate in the lateral two-thirds of the dLGN even though synaptic sites are vacated throughout the nucleus. We suggest that this preference may be due to a specificity of the colliculogeniculate fibers for the lateral two-thirds of the dLGN, which, in normal adult tree shrews, contains cells with similar physiological characteristics. We further suggest that the normal lamination of the colliculogeniculate projection in the lateral two- thirds of the dLGN may be due to competition with retinogeniculate fibers so that colliculogeniculate fibers terminate predominantly in layers containing small, W-like cells.

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help