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Journal of Neuroscience, Vol 8, 754-764, Copyright © 1988 by Society for Neuroscience
Single unit analysis of the human ventral thalamic nuclear group: correlation of thalamic "tremor cells" with the 3-6 Hz component of parkinsonian tremor
FA Lenz, RR Tasker, HC Kwan, S Schnider, R Kwong, Y Murayama, JO Dostrovsky and JT Murphy
Division of Neurosurgery, Toronto General Hospital, Canada.
Although cells firing at tremor frequency, called "tremor cells" (Guiot et
al., 1962), have often been recorded in the thalamus of parkinsonian
patients, the extent of correlation between these spike trains and tremor
has rarely been assessed quantitatively. This paper describes spectral
cross-correlation functions calculated between the activity of "tremor
cells" and electromyogram (EMG) signals recorded from several muscles in
the contralateral arm. The power occurring in the spike train at tremor
frequency was described in absolute terms by the spike autopower, and in
relation to the average for all spectral components by the spike autopower
signal-to-noise ratio (spike autopower SNR). The probability of significant
cross-correlation between the thalamic spike train and EMG at tremor
frequency was assessed by the coherence at tremor frequency. Autopower
spectra of the activity of many of these cells exhibited a concentration of
power at tremor frequency, indicated by spike autopower SNRs as high as 18.
Of the EMG signals studied, signals recorded from finger flexors were most
often significantly correlated at tremor frequency. Significant correlation
between the thalamic spike train and finger flexor EMG activity was found
in 34% of cells analyzed. Tremor frequency coherence was significantly
correlated with tremor frequency spike autopower (r = 0.46, p less than
0.0001) and spike autopower SNR (r = 0.533, p less than 0.0001). The
proportion of cells with a spike autopower SNR greater than 2 that were
significantly correlated with finger flexor EMG activity was greater than
that of cells with a spike autopower SNR of less than 2 (p less than 0.001;
chi-square). Therefore, cells exhibiting a large amount of power at tremor
frequency were those best correlated with EMG activity during tremor. Some
of these cells may be involved in the generation of tremor.
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