 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 8, 792-805, Copyright © 1988 by Society for Neuroscience
Development of voltage-dependent calcium, sodium, and potassium currents in Xenopus spinal neurons
DK O'Dowd, AB Ribera and NC Spitzer
Department of Biology, University of California, San Diego, La Jolla 92093.
Action potentials of embryonic nerve and muscle cells often have a
different ionic dependence and longer duration than those of mature cells.
The action potential of spinal cord neurons from Xenopus laevis exhibits a
prominent calcium component at early stages of development that diminishes
with age as the impulse becomes principally sodium dependent. Whole-cell
voltage-clamp analysis has been undertaken to characterize the changes in
membrane currents during development of these neurons in culture. Four
voltage-dependent currents of cells were identified and examined during the
first day in vitro, when most of the change in the action potential occurs.
There are no changes in the peak density of the calcium current (ICa), its
voltage dependence, or time to half-maximal activation; a small increase in
inactivation is apparent. The major change in sodium current (INa) is a
2-fold increase in its density. In addition, more subtle changes in the
kinetics of the macroscopic sodium current were noted. The peak density of
voltage- dependent potassium current (IKv) increases 3-fold, and this
current becomes activated almost twice as fast. No changes were noted in
the extent of its inactivation. The calcium-dependent potassium current
(IKc) consists of an inactivating and a sustained component. The former
increases 2-fold in peak current density, and the latter increases
similarly at less depolarized voltages. The changes in these currents
contribute to the decrease in duration and the change in ionic dependence
of the impulse.
This article has been cited by other articles:
|
|
|
|
 
R. H. Pineda and A. B. Ribera
Dorsal-Ventral Gradient for Neuronal Plasticity in the Embryonic Spinal Cord
J. Neurosci.,
April 2, 2008;
28(14):
3824 - 3834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev,
April 1, 2008;
88(2):
769 - 840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. B. Sann, L. Xu, H. Nishimune, J. R. Sanes, and N. C. Spitzer
Neurite Outgrowth and In Vivo Sensory Innervation Mediated by a CaV2.2-Laminin {beta}2 Stop Signal
J. Neurosci.,
March 5, 2008;
28(10):
2366 - 2374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Nakamura and T. Takahashi
Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal
J. Physiol.,
June 15, 2007;
581(3):
1101 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I-F. Peng and C.-F. Wu
Drosophila cacophony Channels: A Major Mediator of Neuronal Ca2+ Currents and a Trigger for K+ Channel Homeostatic Regulation
J. Neurosci.,
January 31, 2007;
27(5):
1072 - 1081.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. J. Moody and M. M. Bosma
Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells
Physiol Rev,
July 1, 2005;
85(3):
883 - 941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. H. Pineda, R. A. Heiser, and A. B. Ribera
Developmental, Molecular, and Genetic Dissection of INa In Vivo in Embryonic Zebrafish Sensory Neurons
J Neurophysiol,
June 1, 2005;
93(6):
3582 - 3593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Blaine, A. D. Taylor, and A. B. Ribera
Carboxyl Tail Region of the Kv2.2 Subunit Mediates Novel Developmental Regulation of Channel Density
J Neurophysiol,
December 1, 2004;
92(6):
3446 - 3454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kukuljan, A. Taylor, H. Chouinard, P. Olguin, C. V. Rojas, and A. B. Ribera
Selective Regulation of xSlo Splice Variants During Xenopus Embryogenesis
J Neurophysiol,
November 1, 2003;
90(5):
3352 - 3360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hattori, F. Murakami, and W.-J. Song
Quantitative Relationship Between Kv4.2 mRNA and A-Type K+ Current in Rat Striatal Cholinergic Interneurons During Development
J Neurophysiol,
July 1, 2003;
90(1):
175 - 183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. L. Picken Bahrey and W. J. Moody
Early Development of Voltage-Gated Ion Currents and Firing Properties in Neurons of the Mouse Cerebral Cortex
J Neurophysiol,
April 1, 2003;
89(4):
1761 - 1773.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. L. P. Bahrey and W. J. Moody
Voltage-gated Currents, Dye and Electrical Coupling in the Embryonic Mouse Neocortex
Cereb Cortex,
March 1, 2003;
13(3):
239 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. V. Vasilyev and M. E. Barish
Postnatal Development of the Hyperpolarization-Activated Excitatory Current Ih in Mouse Hippocampal Pyramidal Neurons
J. Neurosci.,
October 15, 2002;
22(20):
8992 - 9004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Armisen, R. Fuentes, P. Olguin, M. E. Cabrejos, and M. Kukuljan
Repressor Element-1 Silencing Transcription/Neuron-Restrictive Silencer Factor Is Required for Neural Sodium Channel Expression during Development of Xenopus
J. Neurosci.,
October 1, 2002;
22(19):
8347 - 8351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Mercer and J. G. Hildebrand
Developmental Changes in the Density of Ionic Currents in Antennal-Lobe Neurons of the Sphinx Moth, Manduca sexta
J Neurophysiol,
June 1, 2002;
87(6):
2664 - 2675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Murphy and S. Du Lac
Postnatal Development of Spike Generation in Rat Medial Vestibular Nucleus Neurons
J Neurophysiol,
May 1, 2001;
85(5):
1899 - 1906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Blaine and A. B. Ribera
Kv2 Channels Form Delayed-Rectifier Potassium Channels In Situ
J. Neurosci.,
March 1, 2001;
21(5):
1473 - 1480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Vetter, A. Roth, and M. Hausser
Propagation of Action Potentials in Dendrites Depends on Dendritic Morphology
J Neurophysiol,
February 1, 2001;
85(2):
926 - 937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Vincent, N. J. Lautermilch, and N. C. Spitzer
Antisense Suppression of Potassium Channel Expression Demonstrates Its Role in Maturation of the Action Potential
J. Neurosci.,
August 15, 2000;
20(16):
6087 - 6094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Martin-Caraballo and J. J. Greer
Development of Potassium Conductances in Perinatal Rat Phrenic Motoneurons
J Neurophysiol,
June 1, 2000;
83(6):
3497 - 3508.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. McAnelly and H. H. Zakon
Coregulation of Voltage-Dependent Kinetics of Na+ and K+ Currents in Electric Organ
J. Neurosci.,
May 1, 2000;
20(9):
3408 - 3414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Mleux and L. E. Moore
Firing Properties and Electrotonic Structure of Xenopus Larval Spinal Neurons
J Neurophysiol,
March 1, 2000;
83(3):
1366 - 1380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Mleux and L. E. Moore
Active Dendritic Membrane Properties of Xenopus Larval Spinal Neurons Analyzed With a Whole Cell Soma Voltage Clamp
J Neurophysiol,
March 1, 2000;
83(3):
1381 - 1393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Lazaroff, A. D. Hofmann, and A. B. Ribera
Xenopus Embryonic Spinal Neurons Express Potassium Channel Kvbeta Subunits
J. Neurosci.,
December 15, 1999;
19(24):
10706 - 10715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tanaka, T. R. Cummins, K. Ishikawa, J. A. Black, Y. Ibata, and S. G. Waxman
Molecular and functional remodeling of electrogenic membrane of hypothalamic neurons in response to changes in their input
PNAS,
February 2, 1999;
96(3):
1088 - 1093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Ribera and C. Nusslein-Volhard
Zebrafish Touch-Insensitive Mutants Reveal an Essential Role for the Developmental Regulation of Sodium Current
J. Neurosci.,
November 15, 1998;
18(22):
9181 - 9191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-q. J. Liu and L. K. Kaczmarek
Depolarization Selectively Increases the Expression of the Kv3.1 Potassium Channel in Developing Inferior Colliculus Neurons
J. Neurosci.,
November 1, 1998;
18(21):
8758 - 8769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Hallows and B. L. Tempel
Expression of Kv1.1, a Shaker-Like Potassium Channel, Is Temporally Regulated in Embryonic Neurons and Glia
J. Neurosci.,
August 1, 1998;
18(15):
5682 - 5691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Baines and M. Bate
Electrophysiological Development of Central Neurons in the Drosophila Embryo
J. Neurosci.,
June 15, 1998;
18(12):
4673 - 4683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. L. Gleason and N. C. Spitzer
AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons
J Neurophysiol,
June 1, 1998;
79(6):
2986 - 2998.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-q. J. Liu and L. K. Kaczmarek
The Expression of Two Splice Variants of the Kv3.1 Potassium Channel Gene Is Regulated by Different Signaling Pathways
J. Neurosci.,
April 15, 1998;
18(8):
2881 - 2890.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Marcus and T. J. Carew
Developmental emergence of different forms of neuromodulation in Aplysia sensory neurons
PNAS,
April 14, 1998;
95(8):
4726 - 4731.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. TAKAHASHI and Y. OKAMURA
Ion Channels and Early Development of Neural Cells
Physiol Rev,
April 1, 1998;
78(2):
307 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. White, M. A. Crumling, and S. D. Meriney
Developmental Changes in Calcium Current Pharmacology and Somatostatin Inhibition in Chick Parasympathetic Neurons
J. Neurosci.,
August 15, 1997;
17(16):
6302 - 6313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sugiura and C.-P. Ko
Novel Modulatory Effect of L-Type Calcium Channels at Newly Formed Neuromuscular Junctions
J. Neurosci.,
February 1, 1997;
17(3):
1101 - 1111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Widmer, H. Amerdeil, P. Fontanaud, and M. G. Desarmenien
Postnatal Maturation of Rat Hypothalamoneurohypophysial Neurons: Evidence for a Developmental Decrease in Calcium Entry During Action Potentials
J Neurophysiol,
January 1, 1997;
77(1):
260 - 271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Stoop and M.-m. Poo
Synaptic Modulation by Neurotrophic Factors: Differential and Synergistic Effects of Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor
J. Neurosci.,
May 15, 1996;
16(10):
3256 - 3264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gurantz, A. B. Ribera, and N. C. Spitzer
Temporal Regulation of Shaker- and Shab-Like Potassium Channel Gene Expression in Single Embryonic Spinal Neurons during K+ Current Development
J. Neurosci.,
May 15, 1996;
16(10):
3287 - 3295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
