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Journal of Neuroscience, Vol 8, 988-1000, Copyright © 1988 by Society for Neuroscience
Heterogeneity of GABAergic cells in cat visual cortex
H Demeulemeester, F Vandesande, GA Orban, C Brandon and JJ Vanderhaeghen
Labortory of Neuroendocrinology and Immunological Biotechnology, Zoological Institute, Leuven, Belgium.
Antibodies against neuropeptides and against a vitamin D-dependent
calcium-binding protein (CaBP) label small cells with nonpyramidal-like
morphology in the cat visual cortex (areas 17, 18, and 19). Since GABAergic
cells are interneurons, a double-staining procedure was used to test for
the coexistence of cholecystokinin (CCK), somatostatin (SRIF), neuropeptide
Y (NPY), corticotropin-releasing factor (CRF), vasoactive intestinal
polypeptide (VIP), and CaBP with glutamic acid decarboxylase (GAD). Our
results show that CRF and VIP do not coexist with GAD, while the 3 other
peptides and CaBP do. Hence GAD-positive cells can be subdivided into 4
broad groups: (1) cells that are only GAD-positive, (2) cells that are GAD-
and CaBP-positive, (3) GAD- positive neurons also containing CCK, and (4)
GAD-positive cells that also contain SRIF. A small subset of class 2 also
contains SRIF and most cells of class 4 also contain NPY. The 4 classes of
GAD-positive cells differ in laminar position: class 1 predominates in
layers IV and V, classes 2 and 3 in the upper laminae (II and III), and
class 4 in the deepest layer (VI).
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