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Journal of Neuroscience, Vol 8, 1901-1904, Copyright © 1988 by Society for Neuroscience
Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain
JN Wilcox and R Derynck
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
The distribution of transforming growth factor (TGF)-alpha and TGF-beta 1
mRNA containing cells in adult mouse brain was examined using in situ
hybridization histochemistry. There were no detectable TGF-beta 1 mRNA-
containing cells found in the brain. TGF-alpha mRNA was localized to cell
bodies of the caudate nucleus, dentate gyrus, anterior olfactory nuclei,
and a laminar distribution of mitral cells in the olfactory bulb.
TGF-alpha-synthesizing cells were localized in brain regions that have been
shown to synthesize nerve growth factor, epidermal growth factor (EGF) and
enkephalins. The function of local synthesis of TGF- alpha in the brain is
as yet unknown.
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