 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 8, 2049-2061, Copyright © 1988 by Society for Neuroscience
Identification and characterization of neurons initiating patterned neural activity in the buccal ganglia of Aplysia
AJ Susswein and JH Byrne
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.
Two patterns of neural activity were identified in excised buccal ganglia
of Aplysia californica. Both are expressed in many cells, and each can be
expressed independently. Using cells B4 and B5 as monitors of the activity
patterns, we searched the buccal ganglia for cells initiating the patterns.
Two electrically coupled cells, B31 and B32, can initiate what we termed
pattern 2. The cells are active before pattern 2 is expressed. Stimuli
initiating pattern 2 excite B31/B32. Depolarizing B31/B32 induces the
pattern, while hyperpolarizing them can prevent its expression. The cells
have unusual features. Their somata do not sustain conventional action
potentials, and depolarization causes a regenerative response. B33 differs
from B31/B32 in that its soma sustains conventional action potentials but
otherwise has similar features. B34 also seems to be inexcitable but has
weaker synaptic input than B31/B32 and appears unable to induce pattern 2.
B35 and B36 have prominent regenerative capabilities. B35 is also able to
initiate pattern 2. B37 is presynaptic to B31/B32 and can initiate pattern
2 via its effects on them. The newly identified cells provide a starting
point for investigating factors that initiate and control different
patterns of neural activity in the buccal ganglia. Since the buccal ganglia
are involved in generating feeding behavior, further studies on the newly
identified cells may provide insights into the neural control of feeding
behavior, and provide a neural substrate for studying modulation of the
feeding patterns by associative learning.
This article has been cited by other articles:
|
|
|
|
 
D. Levitan, L. C. Lyons, A. Perelman, C. L. Green, B. Motro, A. Eskin, and A. J. Susswein
Training with inedible food in Aplysia causes expression of C/EBP in the buccal but not cerebral ganglion
Learn. Mem.,
May 28, 2008;
15(6):
412 - 416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Hurwitz, A. Ophir, A. Korngreen, J. Koester, and A. J. Susswein
Currents Contributing to Decision Making in Neurons B31/B32 of Aplysia
J Neurophysiol,
February 1, 2008;
99(2):
814 - 830.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Sasaki, M. R. Due, J. Jing, and K. R. Weiss
Feeding CPG in Aplysia Directly Controls Two Distinct Outputs of a Compartmentalized Interneuron That Functions as a CPG Element
J Neurophysiol,
December 1, 2007;
98(6):
3796 - 3801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Serrano, C. Martinez-Rubio, and M. W. Miller
Endogenous Motor Neuron Properties Contribute to a Program-Specific Phase of Activity in the Multifunctional Feeding Central Pattern Generator of Aplysia
J Neurophysiol,
July 1, 2007;
98(1):
29 - 42.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Baxter and J. H. Byrne
Feeding behavior of Aplysia: A model system for comparing cellular mechanisms of classical and operant conditioning
Learn. Mem.,
November 1, 2006;
13(6):
669 - 680.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Serrano and M. W. Miller
Conditional Rhythmicity and Synchrony in a Bilateral Pair of Bursting Motor Neurons in Aplysia
J Neurophysiol,
October 1, 2006;
96(4):
2056 - 2071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhurov, A. Proekt, K. R. Weiss, and V. Brezina
Changes of Internal State Are Expressed in Coherent Shifts of Neuromuscular Activity in Aplysia Feeding Behavior
J. Neurosci.,
February 2, 2005;
25(5):
1268 - 1280.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Hurwitz, A. J. Susswein, and K. R. Weiss
Transforming Tonic Firing Into a Rhythmic Output in the Aplysia Feeding System: Presynaptic Inhibition of a Command-Like Neuron by a CPG Element
J Neurophysiol,
February 1, 2005;
93(2):
829 - 842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Dembrow, J. Jing, V. Brezina, and K. R. Weiss
A Specific Synaptic Pathway Activates a Conditional Plateau Potential Underlying Protraction Phase in the Aplysia Feeding Central Pattern Generator
J. Neurosci.,
June 2, 2004;
24(22):
5230 - 5238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Mozzachiodi, H. A. Lechner, D. A. Baxter, and J. H. Byrne
In Vitro Analog of Classical Conditioning of Feeding Behavior in Aplysia
Learn. Mem.,
November 1, 2003;
10(6):
478 - 494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Dembrow, J. Jing, A. Proekt, A. Romero, F. S. Vilim, E. C. Cropper, and K. R. Weiss
A Newly Identified Buccal Interneuron Initiates and Modulates Feeding Motor Programs in Aplysia
J Neurophysiol,
October 1, 2003;
90(4):
2190 - 2204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Furukawa, K. Nakamaru, K. Sasaki, Y. Fujisawa, H. Minakata, S. Ohta, F. Morishita, O. Matsushima, L. Li, V. Alexeeva, et al.
PRQFVamide, a Novel Pentapeptide Identified From the CNS and Gut of Aplysia
J Neurophysiol,
June 1, 2003;
89(6):
3114 - 3127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Hurwitz, I. Kupfermann, and K. R. Weiss
Fast Synaptic Connections From CBIs to Pattern-Generating Neurons in Aplysia: Initiation and Modification of Motor Programs
J Neurophysiol,
April 1, 2003;
89(4):
2120 - 2136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Katzoff, T. Ben-Gedalya, and A. J. Susswein
Nitric Oxide Is Necessary for Multiple Memory Processes after Learning That a Food Is Inedible in Aplysia
J. Neurosci.,
November 1, 2002;
22(21):
9581 - 9594.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Jing and K. R. Weiss
Interneuronal Basis of the Generation of Related but Distinct Motor Programs in Aplysia: Implications for Current Neuronal Models of Vertebrate Intralimb Coordination
J. Neurosci.,
July 15, 2002;
22(14):
6228 - 6238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Susswein, I. Hurwitz, R. Thorne, J. H. Byrne, and D. A. Baxter
Mechanisms Underlying Fictive Feeding in Aplysia: Coupling Between a Large Neuron With Plateau Potentials Activity and a Spiking Neuron
J Neurophysiol,
May 1, 2002;
87(5):
2307 - 2323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. H. Elliott and A. J. Susswein
Comparative neuroethology of feeding control in molluscs
J. Exp. Biol.,
April 1, 2002;
205(7):
877 - 896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Neustadter, R. F. Drushel, and H. J. Chiel
Kinematics of the buccal mass during swallowing based on magnetic resonance imaging in intact, behaving Aplysia californica
J. Exp. Biol.,
April 1, 2002;
205(7):
939 - 958.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. T. Morgan, J. Jing, F. S. Vilim, and K. R. Weiss
Interneuronal and Peptidergic Control of Motor Pattern Switching in Aplysia
J Neurophysiol,
January 1, 2002;
87(1):
49 - 61.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Jing and K. R. Weiss
Neural Mechanisms of Motor Program Switching in Aplysia
J. Neurosci.,
September 15, 2001;
21(18):
7349 - 7362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. V. Orekhova, J. Jing, V. Brezina, R. A. DiCaprio, K. R. Weiss, and E. C. Cropper
Sonometric Measurements of Motor-Neuron-Evoked Movements of an Internal Feeding Structure (the Radula) in Aplysia
J Neurophysiol,
August 1, 2001;
86(2):
1057 - 1061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Kemenes, K. Staras, and P. R. Benjamin
Multiple Types of Control by Identified Interneurons in a Sensory-Activated Rhythmic Motor Pattern
J. Neurosci.,
April 15, 2001;
21(8):
2903 - 2911.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Hurwitz, E. C. Cropper, F. S. Vilim, V. Alexeeva, A. J. Susswein, I. Kupfermann, and K. R. Weiss
Serotonergic and Peptidergic Modulation of the Buccal Mass Protractor Muscle (I2) in Aplysia
J Neurophysiol,
December 1, 2000;
84(6):
2810 - 2820.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. D. Sanchez, Y. Li, and M. D. Kirk
Regeneration of Cerebral-Buccal Interneurons and Recovery of Ingestion Buccal Motor Programs in Aplysia After CNS Lesions
J Neurophysiol,
December 1, 2000;
84(6):
2961 - 2974.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Deodhar and I. Kupfermann
Studies of Neuromodulation of Oscillatory Systems in Aplysia, by Means of Genetic Algorithms
Adaptive Behavior,
June 1, 2000;
8(3-4):
267 - 296.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. A. Lechner, D. A. Baxter, and J. H. Byrne
Classical Conditioning of Feeding in Aplysia: II. Neurophysiological Correlates
J. Neurosci.,
May 1, 2000;
20(9):
3377 - 3386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Rosen, M. W. Miller, C. G. Evans, E. C. Cropper, and I. Kupfermann
Diverse Synaptic Connections Between Peptidergic Radula Mechanoafferent Neurons and Neurons in the Feeding System of Aplysia
J Neurophysiol,
March 1, 2000;
83(3):
1605 - 1620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Kabotyanski, D. A. Baxter, S. J. Cushman, and J. H. Byrne
Modulation of Fictive Feeding by Dopamine and Serotonin in Aplysia
J Neurophysiol,
January 1, 2000;
83(1):
374 - 392.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nagahama, K. Narusuye, and H. Arai
Synaptic Modulation Contributes to Firing Pattern Generation in Jaw Motor Neurons During Rejection of Seaweed in Aplysia kurodai
J Neurophysiol,
November 1, 1999;
82(5):
2579 - 2589.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nargeot, D. A. Baxter, and J. H. Byrne
In Vitro Analog of Operant Conditioning in Aplysia. I. Contingent Reinforcement Modifies the Functional Dynamics of an Identified Neuron
J. Neurosci.,
March 15, 1999;
19(6):
2247 - 2260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nargeot, D. A. Baxter, and J. H. Byrne
In Vitro Analog of Operant Conditioning in Aplysia. II. Modifications of the Functional Dynamics of an Identified Neuron Contribute to Motor Pattern Selection
J. Neurosci.,
March 15, 1999;
19(6):
2261 - 2272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Xin, I. Hurwitz, R. Perrins, C. G. Evans, V. Alexeeva, K. R. Weiss, and I. Kupfermann
Actions of a Pair of Identified Cerebral-Buccal Interneurons (CBI-8/9) in Aplysia That Contain the Peptide Myomodulin
J Neurophysiol,
February 1, 1999;
81(2):
507 - 520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. G. Evans, V. Alexeeva, J. Rybak, T. Karhunen, K. R. Weiss, and E. C. Cropper
A Pair of Reciprocally Inhibitory Histaminergic Sensory Neurons Are Activated within the Same Phase of Ingestive Motor Programs in Aplysia
J. Neurosci.,
January 15, 1999;
19(2):
845 - 858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Botzer, S. Markovich, and A. J. Susswein
Multiple Memory Processes Following Training That a Food Is Inedible in Aplysia
Learn. Mem.,
July 1, 1998;
5(3):
204 - 219.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. Perrins and K. R. Weiss
Compartmentalization of Information Processing in an Aplysia Feeding Circuit Interneuron through Membrane Properties and Synaptic Interactions
J. Neurosci.,
May 15, 1998;
18(10):
3977 - 3989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Kabotyanski, D. A. Baxter, and J. H. Byrne
Identification and Characterization of Catecholaminergic Neuron B65, Which Initiates and Modifies Patterned Activity in the Buccal Ganglia of Aplysia
J Neurophysiol,
February 1, 1998;
79(2):
605 - 621.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Brierley, M. S. Yeoman, and P. R. Benjamin
Glutamatergic N2v Cells Are Central Pattern Generator Interneurons of the Lymnaea Feeding System: New Model for Rhythm Generation
J Neurophysiol,
December 1, 1997;
78(6):
3396 - 3407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nargeot, D. A. Baxter, and J. H. Byrne
Contingent-Dependent Enhancement of Rhythmic Motor Patterns: An In Vitro Analog of Operant Conditioning
J. Neurosci.,
November 1, 1997;
17(21):
8093 - 8105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Hurwitz, I. Kupfermann, and A. J. Susswein
Different Roles of Neurons B63 and B34 That Are Active During the Protraction Phase of Buccal Motor Programs in Aplysia californica
J Neurophysiol,
September 1, 1997;
78(3):
1305 - 1319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Perrins and K. R. Weiss
A Cerebral Central Pattern Generator in Aplysia and Its Connections with Buccal Feeding Circuitry
J. Neurosci.,
November 1, 1996;
16(21):
7030 - 7045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. D. Sanchez and M. D. Kirk
Short-Term Synaptic Enhancement Modulates Ingestion Motor Programs of Aplysia
J. Neurosci.,
July 15, 2000;
20(14):
RC85 - RC85.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
