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Journal of Neuroscience, Vol 8, 2183-2200, Copyright © 1988 by Society for Neuroscience
The overall pattern of ocular dominance bands in cat visual cortex
PA Anderson, J Olavarria and RC Van Sluyters
School of Optometry, University of California, Berkeley 94720.
This study describes the overall arrangement of geniculocortical input
representing the system of cortical ocular dominance bands in layer IV of
striate cortex in the adult cat. The pattern of ocular dominance bands was
revealed by transneuronal transport of the intraocularly injected tracer
wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP). Our
data indicate that this procedure does not damage the retina and that it
results in relatively uniform uptake and transport of the tracer. Using
previously published techniques (Olavarria and Van Sluyters, 1983, 1985),
both cortical hemispheres of each cat were unfolded, flattened and
tangentially sectioned. Analysis of the WGA-HRP labeling patterns in these
sections revealed a relatively continuous network of irregularly branching
bands in layer IV of area 17 in both hemispheres. Because of a systematic
difference in the level of interband labeling, ocular dominance bands
appear less distinct in the hemisphere contralateral to the injected eye.
There is also a tendency for interband labeling to be greater in cortical
regions that represent the more peripheral aspects of the binocular portion
of the visual field. The width of an individual ocular dominance band in
the cat fluctuates, so that it appears to be made up of a series of
uniformly sized, roughly circular beads of label. The diameter of these
beads averages 667 micron, and preliminary counts indicate that there are
650-675 beads in each striate cortex. Contrary to earlier suggestions, in 4
out of 6 hemispheres analyzed quantitatively there was no tendency for
ocular dominance bands to be oriented along a preferred axis in cat striate
cortex, including an axis orthogonal to the border between areas 17 and 18.
Ocular dominance bands in area 18 appear to be broader than those in area
17, and they seem to have a greater tendency to be oriented orthogonal to
the 17/18 border than those in area 17. Compared with the ocular dominance
pattern in monkey striate cortex, the ocular dominance pattern in the cat
is much less regular. In general, cat ocular dominance bands appear to
fluctuate more in width, to change direction more often, and to be less
likely to run orthogonal to the 17/18 border. The greater regularity of the
primate ocular dominance pattern may be related to differences in the way
in which the visual hemifield is mapped onto the striate cortex in these 2
species.
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