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Journal of Neuroscience, Vol 8, 2394-2405, Copyright © 1988 by Society for Neuroscience
Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
RM Lindsay
Sandoz Institute for Medical Research, London, England.
Largely on the basis of studies with nerve growth factor (NGF), it is now
widely accepted that development of the peripheral nervous system of
vertebrates is dependent in part on the interaction of immature sensory and
autonomic neurons with specific survival factors that are derived from
peripheral target fields. I have found, in marked contrast to an absolute
requirement for NGF during development, that adult rat dorsal root ganglion
sensory neurons are not dependent on NGF or other survival factors for
long-term (3-4 weeks) maintenance in vitro. When dissociated and enriched,
at least 70-80% of adult DRG neurons survived and extended long processes
either in the absence of exogenously added NGF or upon the removal of any
possible source of endogenous NGF or other neurotrophic activity (i.e.,
nonneuronal cells, in chemically defined culture medium, in the presence of
an excess of anti-NGF antibodies, or when cultured as single neurons in
microwells). Although not required for survival or expression of a range of
complex morphologies, both NGF and brain-derived neurotrophic factor (BDNF)
were found to stimulate the regeneration of axons from adult DRG neurons.
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