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Journal of Neuroscience, Vol 8, 3144-3150, Copyright © 1988 by Society for Neuroscience
Disconnection of the amygdala from visual association cortex impairs visual reward-association learning in monkeys
EA Gaffan, D Gaffan and S Harrison
Department of Psychology, Reading University, England.
Cynomolgus monkeys (Macaca fascicularis) were trained in a task that
assessed their ability to associate visual stimuli with food reward.
Acquisition of stimulus-reward associations was measured under 2
conditions, a 2-stimuli acquisition condition and a 1-stimulus acquisition
condition. On each trial in the 2-stimuli condition, the positive (correct)
and negative (incorrect) stimuli were presented side by side and the animal
chose one by touching it; if the choice was correct, a food reward was
dispensed. On each trial in the 1-stimulus condition, either the positive
or the negative stimulus was presented alone; if the stimulus was the
positive, it was followed by reward delivery, regardless of the animal's
response to it, and if it was the negative, it was not followed by reward
delivery. Thus, reward delivery was contingent upon the animal's response
to the stimuli in the 2- stimuli condition but not in the 1-stimulus
condition. The effect of acquisition trials under these 2 conditions was
measured, in both conditions, by the animal's subsequent choice when
presented with the 2 stimuli side by side. Following preoperative training
in this task, the animals were first subjected to unilateral ablation of
the inferotemporal cortex. This operation had little effect on the animals'
learning ability. Then, the amygdala was ablated in the hemisphere
contralateral to that in which the unilateral inferotemporal ablation had
been carried out. This combination of crossed unilateral lesions of the
amygdala and of the inferotemporal cortex, which disconnects the amygdala
from the output of visual association cortex, produced a profound
impairment in stimulus-reward-associative learning.(ABSTRACT TRUNCATED AT
250 WORDS)
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