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Journal of Neuroscience, Vol 8, 3160-3180, Copyright © 1988 by Society for Neuroscience
Relationships between segregated afferents and postsynaptic neurones in the optic tectum of three-eyed frogs
LC Katz and M Constantine-Paton
Laboratory of Neurobiology, Rockefeller University, New York, New York 10021.
In 3-eyed frogs, afferents from 2 eyes converge on an optic tectum that
normally receives input from only 1 eye. This produces an interdigitating
series of stripes, resembling the ocular dominance columns in cats and
monkeys. The consequences of this induced striping on the behavior of
tectal dendrites was investigated in an in vitro preparation of the tectum.
Stripes were labeled by anterograde transport of a fluorescent dye
(rhodamine) and postsynaptic tectal cells labeled by intracellular
injections of Lucifer yellow. The same types of cells were present in both
normal and striped tecta, but dendritic arbors were altered in 2 ways. In
normal tecta, dendrites were most frequently biased in a rostral direction.
In striped tecta, dendrites were more frequently unbiased: fewer arbors had
a strong rostral bias. The second effect of stripes was on the behaviors of
individual dendrites of certain cell types. Some cells, primarily those
with small, highly branched arbors, had dendrites that abruptly terminated
at the borders between stripes. Other cells, with larger arbors, maintained
"clumps" of dendrites in both eye's stripes. While these cells had portions
of their dendritic arbor in more than one stripe, each individual dendrite
was restricted to a single stripe. However, the processes of many cells,
especially those with extensive, medial-laterally oriented dendrites, did
not respect stripe boundaries in any obvious fashion. At the border between
2 stripes, there is an abrupt discontinuity in the patterns of activity in
afferent axons. The dendritic alterations seen in striped tecta suggest
that correlated activity can, in some cells, modulate the spatial
arrangement of dendrites, such that an individual dendrite preferentially
arborizes within such areas, but not between them. These cells as a whole
can accommodate uncorrelated inputs, if these are segregated onto separate
dendrites. This implies that local interactions between presynaptic
terminals and postsynaptic dendrites, rather than action potentials in the
postsynaptic cells, may furnish important signals for the modulation of
dendritic arbor shape.
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