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Journal of Neuroscience, Vol 8, 3481-3498, Copyright © 1988 by Society for Neuroscience
An immunohistochemical study of the nerve growth factor receptor in developing rats
Q Yan and EM Johnson Jr
Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110.
Nerve growth factor (NGF) receptor expression was studied in rats between
embryonic day 11 (E11) to postnatal day 10 (PND10) by using a monoclonal
antibody, 192-IgG, that specifically recognizes rat NGF receptor.
Sympathetic ganglia were lightly stained by 192-IgG for NGF receptor
immunoreactivity (NGFRI) (E11-PND10). Neural crest-derived sensory ganglia
were moderately to densely stained (E11-PND10). Areas in CNS innervated by
the central processes of these ganglia were also stained. Parasympathetic
ciliary ganglion showed some detectable staining (E16-PND6).
Placode-derived sensory ganglia were stained more densely than that of
neural crest-derived sensory ganglia. The most densely stained tissue for
NGFRI was found in all peripheral nerves. Basal forebrain cholinergic
neurons were NGFRI positive from E15 throughout the period examined.
Motoneurons in both spinal cord and brain stem were positive for NGFRI
between E15 and PND10. NGFRI staining was seen in a variety of sensory
pathways and related structures, such as olfactory tract and glomerular
layer of olfactory bulb; retina, optic nerve and tract, lateral geniculate
nucleus, medial terminal nucleus of the accessory optic tract, and olivary
pretectal nucleus; ventral cochlear nucleus and to a lesser degree in
dorsal cochlear nucleus, superior olive, and nucleus of lateral lemniscus;
solitary tract; cuneate nucleus, gracile nucleus, and ventroposterior
thalamic nucleus. The specific staining was also found in some other CNS
structures, including brain-stem reticular formation; amygdala; medial
nucleus of inferior olive but not the rest of inferior olive, external
granule cell layer and Purkinje's cells of cerebellum, and deep cerebellar
nuclei. Some non-neuronal tissues such as meninges and dental tissue showed
very distinctive staining. Limb buds and somites were NGFRI positive
starting at E11, and the staining on muscle tissue became very dense at
E15-E18 and largely disappeared around PND10. Embryonic thymus was positive
for NGFRI. The adventitia surrounding blood vessels was very densely
stained. The changes in NGFRI staining seen in this study suggest that NGF
may have broader effects during development than previously thought.
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|
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|
|
|
|
|
|
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18(4):
1297 - 1304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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February 15, 1998;
18(4):
1440 - 1448.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Estevez, N. Spear, S. M. Manuel, R. Radi, C. E. Henderson, L. Barbeito, and J. S. Beckman
Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation
J. Neurosci.,
February 1, 1998;
18(3):
923 - 931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. T. Yeo, J. Chua-Couzens, L. L. Butcher, D. E. Bredesen, J. D. Cooper, J. S. Valletta, W. C. Mobley, and F. M. Longo
Absence of p75NTR Causes Increased Basal Forebrain Cholinergic Neuron Size, Choline Acetyltransferase Activity, and Target Innervation
J. Neurosci.,
October 15, 1997;
17(20):
7594 - 7605.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Dusart, M. S. Airaksinen, and C. Sotelo
Purkinje Cell Survival and Axonal Regeneration Are Age Dependent: An In Vitro Study
J. Neurosci.,
May 15, 1997;
17(10):
3710 - 3726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Yamamoto, J Livet, R. Pollock, A Garces, V Arce, O deLapeyriere, and C. Henderson
Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons
Development,
January 8, 1997;
124(15):
2903 - 2913.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. O. Hiltunen, U. Arumae, M. Moshnyakov, and M. Saarma
Expression of mRNAs for Neurotrophins and Their Receptors in Developing Rat Heart
Circ. Res.,
November 1, 1996;
79(5):
930 - 939.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Lee, K Bachman, S Landis, and R Jaenisch
Dependence on p75 for innervation of some sympathetic targets
Science,
March 11, 1994;
263(5152):
1447 - 1449.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Lee, A. Davies, and R Jaenisch
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
Development,
January 4, 1994;
120(4):
1027 - 1033.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Nakagawara, M. Arima-Nakagawara, N. J. Scavarda, C. G. Azar, A. B. Cantor, and G. M. Brodeur
Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma
N. Engl. J. Med.,
March 25, 1993;
328(12):
847 - 854.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H Sariola, M Saarma, K Sainio, U Arumae, J Palgi, A Vaahtokari, I Thesleff, and A Karavanov
Dependence of kidney morphogenesis on the expression of nerve growth factor receptor
Science,
October 25, 1991;
254(5031):
571 - 573.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Monuki, R Kuhn, G Weinmaster, B. Trapp, and G Lemke
Expression and activity of the POU transcription factor SCIP
Science,
September 14, 1990;
249(4974):
1300 - 1303.
[Abstract]
[PDF]
|
|
|
|
