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Journal of Neuroscience, Vol 8, 3515-3521, Copyright © 1988 by Society for Neuroscience
Axonal regulation of myelin protein mRNA levels in actively myelinating Schwann cells
BD Trapp, P Hauer and G Lemke
Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, Maryland 21205.
Upon transection of a peripheral nerve, axons distal to the transection
degenerate. As a consequence of this axonal degeneration, myelin- forming
Schwann cells cease biosynthesis of new myelin membrane, contribute to
phagocytosis of previously formed myelin, and markedly down-regulate
expression of myelin-specific markers. Among the most prominent of these
down-regulated markers are the major structural proteins of peripheral
myelin, Po and myelin basic protein (MBP). We have used slot blot and in
situ hybridization techniques to demonstrate that for actively myelinating
Schwann cells, down-regulation of the Po and MBP genes occurs primarily at
the level of mRNA expression. Together with other recent data, these
findings strongly argue for axonal modulation of Po and MBP gene
transcription during active myelination.
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