WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Join the AAN today!
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoffman, W. H.
Right arrow Articles by Haberly, L. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoffman, W. H.
Right arrow Articles by Haberly, L. B.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 9, 206-215, Copyright © 1989 by Society for Neuroscience

ARTICLE

Bursting induces persistent all-or-none EPSPs by an NMDA-dependent process in piriform cortex

WH Hoffman and LB Haberly
Neurosciences Training Program, University of Wisconsin, Madison 53706.

Burst responses to stimulation of excitatory fiber tracts in olfactory cortex slices after removal of extracellular Mg2+ or decreases in extracellular Cl-, resulted in long-lasting changes in response properties of neurons following a return to normal bathing medium. After bursting activity, the response of pyramidal cells to stimulation of afferent or associational fiber systems consisted of the normal graded depolarizing postsynaptic potential and a new, high-amplitude depolarizing potential that followed the graded potential at a variable latency. The new late potential had a waveform that resembled the initial graded response, but it occurred in an all-or-none fashion with a discrete threshold and persisted for many hours. Threshold for the late potential was similar for different cells in the same slice and was not affected by intracellular current injection, indicating that a synchronized interaction among a large number of cells is involved in its generation. Properties of the late potential indicate that it is an EPSP. NMDA receptor antagonists (APV and ketamine) had little effect on the late potential but prevented its development if present during bursting activity. The possible relevance of these findings to the study of the neuronal substrate for long-term memory and epilepsy is discussed.


This article has been cited by other articles:


Home page
 Cereb CortexHome page
M. V. Sanchez-Vives, V. F. Descalzo, R. Reig, N. A. Figueroa, A. Compte, and R. Gallego
Rhythmic Spontaneous Activity in the Piriform Cortex
Cereb Cortex, May 1, 2008; 18(5): 1179 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Fontanini and J. M. Bower
Variable Coupling Between Olfactory System Activity and Respiration in Ketamine/Xylazine Anesthetized Rats
J Neurophysiol, June 1, 2005; 93(6): 3573 - 3581.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Demir, L. B. Haberly, and M. B. Jackson
Epileptiform Discharges With In-Vivo-Like Features in Slices of Rat Piriform Cortex With Longitudinal Association Fibers
J Neurophysiol, November 1, 2001; 86(5): 2445 - 2460.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Lynch, U. Sayin, G. Golarai, and T. Sutula
NMDA Receptor-Dependent Plasticity of Granule Cell Spiking in the Dentate Gyrus of Normal and Epileptic Rats
J Neurophysiol, December 1, 2000; 84(6): 2868 - 2879.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Demir, L. B. Haberly, and M. B. Jackson
Characteristics of Plateau Activity During the Latent Period Prior to Epileptiform Discharges in Slices From Rat Piriform Cortex
J Neurophysiol, February 1, 2000; 83(2): 1088 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Demir, L. B. Haberly, and M. B. Jackson
Sustained Plateau Activity Precedes and Can Generate Ictal-Like Discharges in Low-Cl- Medium in Slices from Rat Piriform Cortex
J. Neurosci., December 15, 1999; 19(24): 10738 - 10746.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Demir, L. B. Haberly, and M. B. Jackson
Sustained and Accelerating Activity at Two Discrete Sites Generate Epileptiform Discharges in Slices of Piriform Cortex
J. Neurosci., February 15, 1999; 19(4): 1294 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
Y. Kang, K. Endo, T. Araki, and T. Kaneko
Trans-synaptically Induced Bursts in Regular Spiking Non-pyramidal Cells in Deep Layers of the Cat Motor Cortex
Cereb Cortex, January 1, 1999; 9(1): 77 - 89.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Demir, L. B. Haberly, and M. B. Jackson
Voltage Imaging of Epileptiform Activity in Slices From Rat Piriform Cortex: Onset and Propagation
J Neurophysiol, November 1, 1998; 80(5): 2727 - 2742.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Postlethwaite, A. Constanti, and V. Libri
Muscarinic Agonist-Induced Burst Firing in Immature Rat Olfactory Cortex Neurons In Vitro
J Neurophysiol, April 1, 1998; 79(4): 2003 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. I. Banks, L. B. Haberly, and M. B. Jackson
Layer-Specific Properties of the Transient K Current (IA) in Piriform Cortex
J. Neurosci., June 15, 1996; 16(12): 3862 - 3876.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-