QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pearson, W. L. Articles by Lloyd, P. E. Search for Related Content PubMed PubMed Citation Articles by Pearson, W. L. Articles by Lloyd, P. E.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 9, 318-325, Copyright © 1989 by Society for Neuroscience

ARTICLE

Immunocytological localization of pedal peptide in the central nervous system and periphery of Aplysia

WL Pearson and PE Lloyd
Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637.

Immunocytology using antisera raised to conjugated pedal peptide (Pep) was used to localize the peptide in the CNS and periphery of Aplysia. A total of over 200 neurons in the CNS exhibited Pep-like immunoreactivity. As expected from results presented in the previous paper, immunoreactive neurons were heavily concentrated in the pedal ganglia, primarily in a broad ribbon comprised of about 60 large contiguous neurons on the dorsal side of each ganglion. Smaller and less numerous immunoreactive neurons were found in the other ganglia. A number of neurons primarily located in the abdominal ganglia had dense networks of immunoreactive varicose fibers surrounding their cell bodies. Many immunoreactive axons were observed in peripheral nerves, particularly those nerves leaving the pedal ganglia. Analyses of sections of body wall indicated that Pep-like immunoreactivity was localized to a series of varicose axons that appeared to be associated with vascular spaces, muscle fibers, and other large cells. These axons likely arise from pedal ganglion nerves that were shown to transport large amounts of 35S-labeled Pep to the periphery. These results suggest that Pep is a transmitter-like neuropeptide that is likely to have a number of important physiological actions in Aplysia.

This article has been cited by other articles:

				S. F. Cummins, A. E. Nichols, A. Amare, A. B. Hummon, J. V. Sweedler, and G. T. Nagle Characterization of Aplysia Enticin and Temptin, Two Novel Water-borne Protein Pheromones That Act in Concert with Attractin to Stimulate Mate Attraction J. Biol. Chem., June 11, 2004; 279(24): 25614 - 25622. [Abstract] [Full Text] [PDF]

				L. E. Fox and P. E. Lloyd Glutamate is a Fast Excitatory Transmitter at Some Buccal Neuromuscular Synapses in Aplysia J Neurophysiol, September 1, 1999; 82(3): 1477 - 1488. [Abstract] [Full Text] [PDF]

				G. A. Phares and P. E. Lloyd Immunocytological and Biochemical Localization and Biological Activity of the Newly Sequenced Cerebral Peptide 2 in Aplysia J. Neurosci., December 15, 1996; 16(24): 7841 - 7852. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help