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Journal of Neuroscience, Vol 9, 3584-3589, Copyright © 1989 by Society for Neuroscience
Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats
MJ Christie, JT Williams and RA North
Vollum Institute, Oregon Health Sciences University, Portland 97201.
Locus coeruleus neurons in brain slices prepared from neonatal rats have
rhythmic oscillations in membrane potential at frequencies ranging from 0.3
to 3 Hz. Recordings from pairs of neurons separated by 50-300 microns
showed that this oscillatory activity was synchronized at ages less than 24
d. Slices cut from rats 24-27 d old showed rhythmic activity which was only
partially synchronous between cell pairs, but full synchrony could be
restored by superfusion with tetraethylammonium (2 mM) and/or barium (2
mM). No synchronous rhythmic activity was observed between neurons in
slices from rats 40 d old, even in the presence of tetraethylammonium and
barium. In those cells in which rhythmic potential oscillations were
synchronous, action potentials occurring in one cell were not observed in
the second cell. Electrotonic coupling was directly demonstrated between
41% of neurons (12 of 29 pairs) in slices from rats less than 10 d old but
not in tissue from older rats (4 pairs). The input resistance of neurons
from neonatal rats (less than 15 d old) was about half (81 M omega) that
measured under identical conditions from neurons from adult rats (213 M
omega). The electrotonic potential in cells from rats less than 15 d old
was best fit by a double exponential, whereas that from adults was best fit
by a single exponential. The results demonstrate that significant
electrical coupling occurs among locus coeruleus neurons from neonatal
rats; this appears to decline with age. The coupling serves as a low-pass
filter and causes the synchronized occurrence of membrane potential
oscillations. Such a rhythmic background activity within the entire nucleus
may be important for the widespread trophic role of the noradrenergic
neurons during development.
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