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Journal of Neuroscience, Vol 9, 390-402, Copyright © 1989 by Society for Neuroscience
Selective modulation of spike duration by serotonin and the neuropeptides, FMRFamide, SCPB, buccalin and myomodulin in different classes of mechanoafferent neurons in the cerebral ganglion of Aplysia
SC Rosen, AJ Susswein, EC Cropper, KR Weiss and I Kupfermann
New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
An examination of the cellular properties and synaptic outputs of
mechanoafferent neurons found on the ventrocaudal surface of the cerebral
ganglion of Aplysia indicated that the cerebral mechanoafferent (CM)
neurons are a heterogeneous population of cells. Based on changes in action
potential duration in response to bath applications of 5-HT in the presence
of TEA, CM neurons could be divided into 2 broad classes: mechanoafferents
whose spikes broaden in response to 5-HT (CM-SB neurons) and
mechanoafferents whose spikes narrow in response to 5-HT (CM-SN neurons).
Morphological and electrophysiological studies of the CM-SN neurons
indicated that they were comprised of previously identified interganglionic
cerebral-buccal mechanoafferent (ICBM) neurons and a novel set of sensory
neurons that send an axon into the LLAB cerebral nerve and have perioral
zone receptive fields that are similar to those of ICBM neurons. Changes in
spike width due to 5-HT were correlated with changes in synaptic output as
indicated by the magnitudes of EPSPs evoked in postsynaptic neurons.
Electrical stimulation of cerebral nerves and connectives also produced
spike narrowing or broadening, and the sign of the effect was a function of
the parameters of stimulation. Both heterosynaptic facilitation and
heterosynaptic depression of EPSPs evoked in follower cells could be
demonstrated. A variety of putative neuromodulators other than 5-HT were
also found to affect the duration of action potentials in both classes of
CM neurons. FMRFamide had effects opposite to that of 5-HT. SCPB and a
recently characterized Aplysia neuropeptide, buccalin, broadened the spikes
of both CM classes. Another neuropeptide, myomodulin, decreased the
duration of CM-SB neuron spikes but had no effect on CM-SN spikes. Since
the CM neurons appear to mediate a variety of competing behaviors,
including feeding, locomotion, and defensive withdrawal, the various
neuromodulator actions may contribute to the mechanisms whereby behaviors
are selected and modified.
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