WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience MBF Stereo Investigator
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, P. H.
Right arrow Articles by Hong, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, P. H.
Right arrow Articles by Hong, J. S.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 9, 692-697, Copyright © 1989 by Society for Neuroscience

ARTICLE

Opioids induce convulsions and wet dog shakes in rats: mediation by hippocampal mu, but not delta or kappa opioid receptors

PH Lee, J Obie and JS Hong
Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

The opioid receptor subtypes and brain regions involved in eliciting convulsions and wet dog shakes (WDS) were studied by testing different opioid receptor selective agonists in unanesthetized rats. Selective mu agonists, [NMe-Phe3-D-Pro4]-morphiceptin (PL017) and [D-Ala2-N-methyl- Phe3-Gly5-ol]-enkephalin, induced convulsions and WDS when unilaterally injected into the ventral hippocampus. [D-Ala2,D-Leu5]-enkephalin (DADLE), a mixed mu and delta agonist, also elicited such behavioral changes, but its effect was less potent than the selective mu agonists. DADLE-induced WDS were dose dependent, and both convulsions and WDS were antagonized by the irreversible mu receptor antagonist, beta- funaltrexamine, but not by the selective delta receptor antagonist, ICI- 174,864. Treatment with the selective delta agonist [D-Pen2,5]- enkephalin or the selective kappa agonists U-50,488H, dynorphin-A amide, or dynorphin-A(1-8) did not produce convulsions or WDS. The injection of a high dose of PL017 intraventricularly or into other brain regions such as the dorsal hippocampus, frontal cortex, striatum, and amygdala did not produce convulsions or WDS, therefore suggesting the ventral hippocampus is an important site for the expression of opioid-induced convulsions and WDS. These results suggest that opioid- induced convulsions and WDS are mediated exclusively by mu but not delta or kappa opioid receptors in the ventral hippocampus.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
L. L. Glickfeld, B. V. Atallah, and M. Scanziani
Complementary Modulation of Somatic Inhibition by Opioids and Cannabinoids
J. Neurosci., February 20, 2008; 28(8): 1824 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Formisano, K.-M. Noh, T. Miyawaki, T. Mashiko, M. V. L. Bennett, and R. S. Zukin
Ischemic insults promote epigenetic reprogramming of {micro} opioid receptor expression in hippocampal neurons
PNAS, March 6, 2007; 104(10): 4170 - 4175.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. W. Vaughan and M. Connor
In Search of a Role for the Morphine Metabolite Morphine-3-Glucuronide
Anesth. Analg., August 1, 2003; 97(2): 311 - 312.
[Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-