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Journal of Neuroscience, Vol 9, 914-922, Copyright © 1989 by Society for Neuroscience
Nerve growth factor receptors on normal and injured sensory neurons
VM Verge, RJ Riopelle and PM Richardson
Division of Neurosurgery, Montreal General Hospital, Canada.
The density and binding properties of receptors for nerve growth factor
(NGF) in normal and injured sensory neurons have been analyzed by
quantitative radioautography following incubation of tissue sections with
radioiodinated NGF. The technique is designed to study binding sites that
are half-maximally saturated by picomolar concentrations of NGF: Additional
sites of lower affinity have not been emphasized. In normal adult rats,
approximately half of lumbar sensory neurons have high-affinity receptors
for NGF. One month after the sciatic nerve is cut, the mean number of
high-affinity sites on heavily labeled neurons in the fifth lumbar dorsal
root ganglion falls to less than 20% of normal values because of reduced
receptor density and cell volume. Neurons with high-affinity receptors are
more liable to atrophy after injury than those lacking such receptors.
Receptors are lost not only in the cell bodies of sensory neurons but also
on their peripheral and central processes. Delayed administration of NGF to
the sciatic nerve 3 weeks after it is cut restores the receptor density to
normal values and partially restores the neuronal cell volume. As part of
the response to axonal injury and possibly because the cell body is
deprived of NGF, fewer high-affinity receptors are displayed by sensory
neurons. For at least 3 weeks after nerve transection, neurons that are
atrophic and depleted of NGF receptors can be resuscitated by exogenous
NGF.
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