 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 9, 1097-1111, Copyright © 1989 by Society for Neuroscience
Hippocampal place cells: stereotypy and plasticity
CR Breese, RE Hampson and SA Deadwyler
Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27103.
Hippocampal complex spike cells were recorded during exploration for water
delivered to cups located in various regions of an elevated platform. Place
fields were recorded with a video monitoring system that recorded movements
as the animal explored each of the 5 cup locations where water was
delivered on the platform. Plasticity of place cell firing as a function of
selective water delivery to specific cup locations on the platform was also
examined. Several characteristics of place cell firing were studied that
indicated a high degree of control by factors such as relative direction of
movement and trajectory through the field. Time-shift analyses indicated
cell firing was most representative of the place field at the time of spike
occurrence. It was demonstrated that place fields possess borders in which
firing was increased or decreased upon entering or leaving a particular
region of the platform. The most important finding from this investigation
was the pronounced degree of plasticity exhibited by place cells. Selective
delivery of water to a single location on the platform was sufficient in
most of the cases tested to shift the location of the field to the location
where water was available. These findings suggest hippocampal place cell
firing, although highly influenced by spatial and directional features of
the environment, can readily change under conditions in which significant
stimuli are added or removed from those locations.
This article has been cited by other articles:
|
|
|
|
 
J. J. Siegel, J. P. Neunuebel, and J. J. Knierim
Dominance of the Proximal Coordinate Frame in Determining the Locations of Hippocampal Place Cell Activity During Navigation
J Neurophysiol,
January 1, 2008;
99(1):
60 - 76.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Ainge, M. Tamosiunaite, F. Woergoetter, and P. A. Dudchenko
Hippocampal CA1 Place Cells Encode Intended Destination on a Maze with Multiple Choice Points
J. Neurosci.,
September 5, 2007;
27(36):
9769 - 9779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Griffin, H. Eichenbaum, and M. E. Hasselmo
Spatial Representations of Hippocampal CA1 Neurons Are Modulated by Behavioral Context in a Hippocampus-Dependent Memory Task
J. Neurosci.,
February 28, 2007;
27(9):
2416 - 2423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Smith and S. J. Y. Mizumori
Learning-related development of context-specific neuronal responses to places and events: the hippocampal role in context processing.
J. Neurosci.,
March 22, 2006;
26(12):
3154 - 3163.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Hok, E. Save, P. P. Lenck-Santini, and B. Poucet
Coding for spatial goals in the prelimbic/infralimbic area of the rat frontal cortex
PNAS,
March 22, 2005;
102(12):
4602 - 4607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. P. Moita, S. Rosis, Y. Zhou, J. E. LeDoux, and H. T. Blair
Putting Fear in Its Place: Remapping of Hippocampal Place Cells during Fear Conditioning
J. Neurosci.,
August 4, 2004;
24(31):
7015 - 7023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. P. Battaglia, G. R. Sutherland, and B. L. McNaughton
Local Sensory Cues and Place Cell Directionality: Additional Evidence of Prospective Coding in the Hippocampus
J. Neurosci.,
May 12, 2004;
24(19):
4541 - 4550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Muir and J. S. Taube
The neural correlates of navigation: do head direction and place cells guide spatial behavior?
Behav Cogn Neurosci Rev,
December 1, 2002;
1(4):
297 - 317.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. A. Gusev and D. L. Alkon
Intracellular Correlates of Spatial Memory Acquisition in Hippocampal Slices: Long-Term Disinhibition of CA1 Pyramidal Cells
J Neurophysiol,
August 1, 2001;
86(2):
881 - 899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Hollup, K. G. Kjelstrup, J. Hoff, M.-B. Moser, and E. I. Moser
Impaired Recognition of the Goal Location during Spatial Navigation in Rats with Hippocampal Lesions
J. Neurosci.,
June 15, 2001;
21(12):
4505 - 4513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Hollup, S. Molden, J. G. Donnett, M.-B. Moser, and E. I. Moser
Accumulation of Hippocampal Place Fields at the Goal Location in an Annular Watermaze Task
J. Neurosci.,
March 1, 2001;
21(5):
1635 - 1644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Matsumura, H. Nishijo, R. Tamura, S. Eifuku, S. Endo, and T. Ono
Spatial- and Task-Dependent Neuronal Responses during Real and Virtual Translocation in the Monkey Hippocampal Formation
J. Neurosci.,
March 15, 1999;
19(6):
2381 - 2393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Best and A. M. White
Hippocampal cellular activity: A brief history of space
PNAS,
March 17, 1998;
95(6):
2717 - 2719.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kobayashi, H. Nishijo, M. Fukuda, J. Bures, and T. Ono
Task-Dependent Representations in Rat Hippocampal Place Neurons
J Neurophysiol,
August 1, 1997;
78(2):
597 - 613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Gothard, W. E. Skaggs, and B. L. McNaughton
Dynamics of Mismatch Correction in the Hippocampal Ensemble Code for Space: Interaction between Path Integration and Environmental Cues
J. Neurosci.,
December 15, 1996;
16(24):
8027 - 8040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Bear
A synaptic basis for memory storage in the cerebral cortex
PNAS,
November 26, 1996;
93(24):
13453 - 13459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
