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Journal of Neuroscience, Vol 9, 1774-1780, Copyright © 1989 by Society for Neuroscience
Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia
CH Bailey and M Chen
Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
We have used the gill- and siphon-withdrawal reflex of Aplysia californica
to explore the morphological basis of the synaptic plasticity that
underlies long-term sensitization. In earlier studies (Bailey and Chen,
1983, 1988a), we described 2 classes of structural changes at identified
sensory neuron synapses that occur following long- term sensitization: (1)
increases in the number, size, and vesicle complement of active zones and
(2) an overall increase in the total number of synaptic varicosities per
sensory neuron. In the present study, we have begun to examine which of
these anatomical changes might be necessary for the maintenance of
long-term sensitization by exploring the time course over which they occur
and, in particular, their duration relative to the persistence of the
memory assessed behaviorally. Toward this end we have quantitated changes
in both the total number of varicosities and their active zone morphology
in single HRP-labeled sensory neurons taken from long-term sensitized and
control animals at different intervals (1-2 d, 1 week, and 3 weeks)
following training. We have found that long-term sensitized animals
examined within 48 hr after the completion of training demonstrate an
increase in the total number of varicosities per sensory neuron as well as
an increase in the incidence, size, and vesicle complement of their
synaptic active zones compared with control animals. The increase in the
number of varicosities and active zones persists unchanged for at least 1
week, and the increase in active zone number is only partially reversed at
the end of 3 weeks.(ABSTRACT TRUNCATED AT 250 WORDS)
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