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Journal of Neuroscience, Vol 9, 2382-2390, Copyright © 1989 by Society for Neuroscience
Place cells and silent cells in the hippocampus of freely-behaving rats
LT Thompson and PJ Best
Neuroscience Graduate Program, University of Virginia, Charlottesville 22903.
In the present study, nearly two-thirds of all hippocampal pyramidal units
isolated under barbiturate anesthesia, which maximizes these cell's
activity, were behaviorally silent. These "silent cells" showed no
spontaneous firing activity in the awake, freely-behaving rat. Both
reanesthetization and antidromic stimulation, however, activated these
silent cells. More than 92% of the remaining spontaneously active
hippocampal pyramidal cells recorded from freely-behaving rats were place
cells; i.e., they exhibited spatially specific changes in firing activity
in at least one environment. The firing rates of these place cells varied
depending on the animal's location in this environment. Interestingly many
of these place cells displayed low or no spontaneous activity and no
spatial specificity in other, dissimilar environments; i.e., their lack of
firing in some spatial environments mirrored the behavioral silence of the
more numerous silent cells reported here. In complex information
processing, such as the processing of spatial information by the
hippocampus demonstrated here, neural silence may be as important a signal
as neural activity.
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