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Journal of Neuroscience, Vol 9, 2391-2401, Copyright © 1989 by Society for Neuroscience
Selective distribution of the 57 kDa neural intermediate filament protein in the rat CNS
BA Brody, CA Ley and LM Parysek
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611.
In order to determine the CNS distribution of the 57 kDa neural
intermediate filament protein (NIFP), a specific antiserum was used in
immunofluorescence studies on serial sections taken from each spinal cord
level and at 300-microns intervals through the rat brain. The labeling
pattern was recorded onto camera lucida tracings of adjacent sections
stained with hematoxylin and eosin/luxol fast blue. Three major
immunolocalization patterns were revealed. (1) Both large-caliber and
fine-caliber axons of optic and all brain stem cranial nerves and their
tracts except for the auditory portion of the VIIIth nerve. (2) An
extensive array of fine-caliber fibers in the cerebellar white matter and
brain stem with region-specific variation in pattern and density. Prominent
among the regions with dense arrays of labeled processes were selective
cerebellar afferent systems, particularly olivocerebellar fibers, visual
afferents arising in the retina, and selective regions of reticular
formation. In contrast to the brain stem, the telencephalon contained rare
label. (3) Filamentous labeling of neuronal cytokarya in sensory ganglia
and a small number of CNS nuclear groups, including all autonomic nuclei
and the cholinergic pontine nuclei. On sections of selected CNS regions,
distribution patterns of the 57 kDa NIFP were correlated to results
obtained by in situ hybridization of a cDNA probe for the 57 kDa NIFP. The
data suggest the possible existence of neuronal IF proteins specifically
related to selective anatomic and/or neurotransmitter systems.
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