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Journal of Neuroscience, Vol 9, 2443-2454, Copyright © 1989 by Society for Neuroscience
The location and function of NMDA receptors in cat and kitten visual cortex
K Fox, H Sato and N Daw
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110.
The role of N-methyl-D-aspartate (NMDA) receptors in cat visual cortex was
studied as a function of both layer and age by iontophoresis of the NMDA
antagonist (D)-2-amino-5-phosphonovaleric acid (APV). Effects on both
visual responses and spontaneous activity were observed. In superficial
layers (II and III), D-APV reduced visual responses substantially at all
ages. Iontophoresis of D-APV with 10 nA of ejecting current for 2-3 min was
sufficient to reduce the response to approximately one third of control
levels. The magnitude of the reduction did not vary with age. In granular
and deep layers (IV, V, and VI), D-APV affected the visual response in
young animals but only spontaneous activity in older animals. On average,
visual responses were reduced to about half at 20-23 days of age and to
about 75% at 4 weeks of age but in most cases were not significantly
affected in adults. The rapid change in the functional effect of NMDA
receptors over the third and fourth week in granular and deep layers
suggests a role in development. There was a reasonable age correlation
between the change in effect and the period of geniculocortical afferent
segregation. Further experiments will be necessary to determine whether
NMDA receptors are necessary for segregation to occur. The presence of an
NMDA component to the visual response in the adult in layers II and III
argues either that these layers retain some form of plasticity in the adult
or that NMDA receptors play a role in the transmission of normal visual
input to these layers.
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