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Journal of Neuroscience, Vol 9, 2973-2981, Copyright © 1989 by Society for Neuroscience

ARTICLE

GABA-mediated inhibition of locus coeruleus from the dorsomedial rostral medulla

M Ennis and G Aston-Jones
Department of Biology, New York University, New York 10003.

Recent anatomic studies in our laboratory (Aston-Jones et al., 1986) identified the nucleus prepositus hypoglossi (PrH) in the dorsomedial medulla as a major afferent of the locus coeruleus (LC). In the present studies, the influence of projections from PrH to LC was assessed in anesthetized rats. Focal electrical stimulation of PrH inhibited the spontaneous discharge of 42 of 47 LC neurons; the latency to onset of such inhibition was 19.8 +/- 2.5 msec and its duration was 172.4 +/- 10.4 msec. PrH-evoked inhibition of LC neurons was unaffected by administration of the opiate receptor antagonist naloxone or the alpha 2-receptor antagonist idazoxan but was substantially reduced by systemic picrotoxin, an antagonist of GABA. The GABAA receptor antagonist bicuculline methiodide blocked the inhibition from PrH, whether applied by local microinfusion or iontophoresis into the LC. These results lead us to propose that PrH provides a direct inhibitory synaptic input to LC, for which GABA is the likely transmitter.

This article has been cited by other articles:

				G. Aston-Jones, Y. Zhu, and J. P. Card Numerous GABAergic Afferents to Locus Ceruleus in the Pericerulear Dendritic Zone: Possible Interneuronal Pool J. Neurosci., March 3, 2004; 24(9): 2313 - 2321. [Abstract] [Full Text] [PDF]

				Y.-Z. Pan, D.-P. Li, S.-R. Chen, and H.-L. Pan Activation of delta -Opioid Receptors Excites Spinally Projecting Locus Coeruleus Neurons Through Inhibition of GABAergic Inputs J Neurophysiol, November 1, 2002; 88(5): 2675 - 2683. [Abstract] [Full Text] [PDF]

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