 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 9, 3072-3082, Copyright © 1989 by Society for Neuroscience
Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis
JP Herman, MK Schafer, EA Young, R Thompson, J Douglass, H Akil and SJ Watson
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
Expression of mRNAs coding for the ACTH secretagogues corticotropin-
releasing factor (CRF) and arginine vasopressin (AVP) was examined in the
hypothalamic paraventricular nucleus (PVN) of rats bearing hippocampal
lesions. Either total hippocampectomy (HPX) or extirpation of the dorsal
hippocampus (DHPX) precipitated a 4-fold increase in CRF mRNA expression
relative to sham-operated controls (SHAM), as determined by
semiquantitative in situ hybridization histochemistry. AVP mRNA was
localized to individual parvocellular neurons of the medial parvocellular
division of the PVN in only the HPX and DHPX groups, consistent with
enhanced production of AVP message in this neuronal population subsequent
to hippocampal damage. HPX did not affect AVP mRNA content in magnocellular
divisions of PVN. Plasma beta- endorphin levels were significantly elevated
in the HPX and DHPX groups relative to SHAM animals, indicating a chronic
increase in release of proopiomelanocortin peptides from the anterior
pituitary gland in response to hippocampal lesion. Circulating
corticosterone levels were elevated in HPX rats as well. To control for
effects of lesion size and location, additional animals received large
ablations of cerebral cortex or cerebellum. In neither case was CRF or AVP
mRNA significantly altered in the PVN. The results suggest that the
hippocampus exercises a tonic inhibitory role on ACTH secretagogue
production in neuroendocrine neurons promoting ACTH release.
This article has been cited by other articles:
|
|
|
|
 
A. R. Furay, A. E. Bruestle, and J. P. Herman
The Role of the Forebrain Glucocorticoid Receptor in Acute and Chronic Stress
Endocrinology,
November 1, 2008;
149(11):
5482 - 5490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Haley and F. W. Flynn
Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2008;
295(4):
R1158 - R1167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ballmaier, K. L. Narr, A. W. Toga, V. Elderkin-Thompson, P. M. Thompson, L. Hamilton, E. Haroon, D. Pham, A. Heinz, and A. Kumar
Hippocampal Morphology and Distinguishing Late-Onset From Early-Onset Elderly Depression
Am J Psychiatry,
February 1, 2008;
165(2):
229 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Mitsushima, K. Takase, T. Funabashi, and F. Kimura
Gonadal Steroid Hormones Maintain the Stress-Induced Acetylcholine Release in the Hippocampus: Simultaneous Measurements of the Extracellular Acetylcholine and Serum Corticosterone Levels in the Same Subjects
Endocrinology,
February 1, 2008;
149(2):
802 - 811.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Wei, E. K. Hebda-Bauer, A. Pletsch, J. Luo, M. T. Hoversten, A. J. Osetek, S. J. Evans, S. J. Watson, A. F. Seasholtz, and H. Akil
Overexpressing the Glucocorticoid Receptor in Forebrain Causes an Aging-Like Neuroendocrine Phenotype and Mild Cognitive Dysfunction
J. Neurosci.,
August 15, 2007;
27(33):
8836 - 8844.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Choi, A. R. Furay, N. K. Evanson, M. M. Ostrander, Y. M. Ulrich-Lai, and J. P. Herman
Bed Nucleus of the Stria Terminalis Subregions Differentially Regulate Hypothalamic-Pituitary-Adrenal Axis Activity: Implications for the Integration of Limbic Inputs
J. Neurosci.,
February 21, 2007;
27(8):
2025 - 2034.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Shoener, R. Baig, and K. C. Page
Prenatal exposure to dexamethasone alters hippocampal drive on hypothalamic-pituitary-adrenal axis activity in adult male rats
Am J Physiol Regulatory Integrative Comp Physiol,
May 1, 2006;
290(5):
R1366 - R1373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Conrad
What Is the Functional Significance of Chronic Stress-Induced CA3 Dendritic Retraction Within the Hippocampus?
Behav Cogn Neurosci Rev,
March 1, 2006;
5(1):
41 - 60.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Wellhoener, J. Born, H. L. Fehm, and C. Dodt
Elevated Resting and Exercise-Induced Cortisol Levels after Mineralocorticoid Receptor Blockade with Canrenoate in Healthy Humans
J. Clin. Endocrinol. Metab.,
October 1, 2004;
89(10):
5048 - 5052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Otte, A. Yassouridis, H. Jahn, P. Maass, N. Stober, K. Wiedemann, and M. Kellner
Mineralocorticoid Receptor-Mediated Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Aged Humans
J. Gerontol. A Biol. Sci. Med. Sci.,
October 1, 2003;
58(10):
B900 - 905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Droste, A. Gesing, S. Ulbricht, M. B. Muller, A. C. E. Linthorst, and J. M. H. M. Reul
Effects of Long-Term Voluntary Exercise on the Mouse Hypothalamic-Pituitary-Adrenocortical Axis
Endocrinology,
July 1, 2003;
144(7):
3012 - 3023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. A. Tuvnes, H.-A. Steffenach, R. Murison, M.-B. Moser, and E. I. Moser
Selective Hippocampal Lesions Do Not Increase Adrenocortical Activity
J. Neurosci.,
May 15, 2003;
23(10):
4345 - 4354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Laugero, F. Gomez, S. Manalo, and M. F. Dallman
Corticosterone Infused Intracerebroventricularly Inhibits Energy Storage and Stimulates the Hypothalamo-Pituitary Axis in Adrenalectomized Rats Drinking Sucrose
Endocrinology,
December 1, 2002;
143(12):
4552 - 4562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Vyas, R. Mitra, B. S. Shankaranarayana Rao, and S. Chattarji
Chronic Stress Induces Contrasting Patterns of Dendritic Remodeling in Hippocampal and Amygdaloid Neurons
J. Neurosci.,
August 1, 2002;
22(15):
6810 - 6818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Gould and C. G. Gross
Neurogenesis in Adult Mammals: Some Progress and Problems
J. Neurosci.,
February 1, 2002;
22(3):
619 - 623.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Veldhuis, A. Iranmanesh, D. Naftolowitz, N. Tatham, F. Cassidy, and B. J. Carroll
Corticotropin Secretory Dynamics in Humans under Low Glucocorticoid Feedback
J. Clin. Endocrinol. Metab.,
November 1, 2001;
86(11):
5554 - 5563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Pacak and M. Palkovits
Stressor Specificity of Central Neuroendocrine Responses: Implications for Stress-Related Disorders
Endocr. Rev.,
August 1, 2001;
22(4):
502 - 548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Laugero, M. E. Bell, S. Bhatnagar, L. Soriano, and M. F. Dallman
Sucrose Ingestion Normalizes Central Expression of Corticotropin-Releasing-Factor Messenger Ribonucleic Acid and Energy Balance in Adrenalectomized Rats: A Glucocorticoid-Metabolic-Brain Axis?
Endocrinology,
July 1, 2001;
142(7):
2796 - 2804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Avishai-Eliner, M. Eghbal-Ahmadi, E. Tabachnik, K. L. Brunson, and T. Z. Baram
Down-Regulation of Hypothalamic Corticotropin-Releasing Hormone Messenger Ribonucleic Acid (mRNA) Precedes Early-Life Experience-Induced Changes in Hippocampal Glucocorticoid Receptor mRNA
Endocrinology,
January 1, 2001;
142(1):
89 - 97.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kabbaj, D. P. Devine, V. R. Savage, and H. Akil
Neurobiological Correlates of Individual Differences in Novelty-Seeking Behavior in the Rat: Differential Expression of Stress-Related Molecules
J. Neurosci.,
September 15, 2000;
20(18):
6983 - 6988.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Bowers, W. E. Cullinan, and J. P. Herman
Region-Specific Regulation of Glutamic Acid Decarboxylase (GAD) mRNA Expression in Central Stress Circuits
J. Neurosci.,
August 1, 1998;
18(15):
5938 - 5947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. R. de Kloet, E. Vreugdenhil, M. S. Oitzl, and M. Joëls
Brain Corticosteroid Receptor Balance in Health and Disease
Endocr. Rev.,
June 1, 1998;
19(3):
269 - 301.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. S. Duman, V. A. Vaidya, M. Nibuya, S. Morinobu, and L. R. Fitzgerald
Review : Stress, Antidepressant Treatments, and Neurotrophic Factors: Molecular and Cellular Mechanisms
Neuroscientist,
November 1, 1995;
1(6):
351 - 360.
[Abstract]
[PDF]
|
|
|
|
