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Journal of Neuroscience, Vol 9, 3169-3175, Copyright © 1989 by Society for Neuroscience
Calcium current in cortical astrocytes: induction by cAMP and neurotransmitters and permissive effect of serum factors
BA Barres, LL Chun and DP Corey
Program in Neuroscience, Harvard Medical School, Boston, Massachusetts.
Voltage-dependent L-type calcium channels were induced in highly purified,
cultured, cortical astrocytes by exposure to substances known to increase
their intracellular cAMP: 8-bromo-cAMP, forskolin, isoproterenol, and
vasoactive intestinal peptide. In untreated control cultures, L-type
calcium currents were entirely absent. The induction of this calcium
current was specific to cortical astrocytes and a closely related astrocyte
type in white matter and did not occur in meningeal cells or
oligodendrocytes. The ability of forskolin to induce L-type calcium current
in astrocytes depended on previous culture of these cells in a permissive
lot of serum for at least 48 hr. In addition, certain lots of sera caused
expression of a voltage-dependent T-type calcium channel in untreated
control cultures. Several possible mechanisms of calcium channel induction
by cAMP are consistent with our data: modification of a silent channel
already present in the membrane, indirect effect of cytoskeletal
alteration, or insertion of channels from submembrane stores. If the
environment in vivo is permissive, regulation of glial ion channels may be
under neuronal control.
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