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Journal of Neuroscience, Vol 9, 3218-3229, Copyright © 1989 by Society for Neuroscience

ARTICLE

Modulation of ionic currents in Aplysia motor neuron B15 by serotonin, neuropeptides, and second messengers

R Taussig, A Sweet-Cordero and RH Scheller
Department of Biological Sciences, Stanford University, California 94305.

Both 5-HT and the 9 amino acid neuropeptide SCPb modulate 3 ionic currents in B15, enhancing a voltage-dependent inward sodium current, decreasing an outward potassium current and increasing an inward rectifying potassium current. In contrast, FMRFamide decreases a voltage-dependent inward sodium current and increases an outward potassium current. We have also investigated the roles of several second-messenger systems that may be mediating the effects of these modulators. Bath application of membrane permeable analogs of cAMP enhance the voltage-dependent inward sodium current and both 5-HT and SCPb increase cAMP levels in B15, suggesting that cAMP may be mediating part of the observed effects of these transmitters on B15. Experiments with phorbol ester, a protein kinase inhibitor, and a phospholipase inhibitor suggest that the phospholipase C/protein kinase C cascade may decrease an outward potassium current. Thus, 5-HT and SCPb may activate multiple second-messenger systems to modulate 3 ionic currents in B15. Additional studies suggest that a cascade involving arachidonic acid may be involved in mediating part of the FMRFamide responses in B15. These studies are beginning to define molecular mechanisms whereby a neuron differentially modulates multiple ionic currents in response to distinct chemical messengers.

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				N. Buttner and S. A. Siegelbaum Antagonistic Modulation of a Hyperpolarization-Activated Cl- Current in Aplysia Sensory Neurons by SCPB and FMRFamide J Neurophysiol, August 1, 2003; 90(2): 586 - 598. [Abstract] [Full Text] [PDF]

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