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Figure 9.
Stages in degenerin-induced cell death. Successive
stages in PVM degeneration are depicted from the production of the
cell-to-cell lysis. The first signs of pathology are the production of
membrane infoldings and whorls. The cytoplasm becomes progressively
less electron-dense as whorls and vacuoles accumulate and enlarge. These vacuoles deform the nucleus and dislocate it toward the plasma
membrane. The axon seems to be disrupted by the middle degeneration
stage. Mitochondria, Golgi, and endoplasmic reticulum, which are
unaffected until late stages in degeneration, are not depicted.
