The Journal of Neuroscience, June 1, 2000, 20(11)
CORRECTION
Correction for Traub et al., A Model of High-Frequency Ripples in the Hippocampus Based on Synaptic Coupling Plus Axon-Axon Gap Junctions between Pyramidal Neurons
Correction: In the article, "A Model of High-Frequency
Ripples in the Hippocampus Based on Synaptic Coupling Plus Axon-Axon Gap Junctions between Pyramidal Neurons," by R. D. Traub and A. Bibbig, which appeared on pages 2086-2093 of the March 15, 2000 issue,
two numbers were reported incorrectly. At the end of the first
paragraph of Results and in the legend of Figure 2C, the mean pyramidal cell signal leads the mean interneuronal signal by 6.0 msec, not the 1.3 msec stated. In the legend of Figure 3, the local
mean interneuron potential lags this axonal signal by 5.6 msec, not the
1.5 msec stated. The authors regret these errors.
In interpreting these numbers, we note the following. In
in vivo experimental studies (e.g., Csicsvári et al.,
1999
) examining the temporal relations of pyramidal cells and
interneurons during ripples, cell pairs are recorded that are usually
within 300 µm of each other, a distance for which axonal conduction
delays are small; in addition, to obtain sufficient unit firings to
collect data for statistical analysis, large numbers (>100) of
separate ripple events were recorded. In the model, data are
pooled from the activity of all of the neurons in our distributed
array, during the course of a single ripple. This introduces axon
conduction delays, which average ~2 msec but can last up to 3.8 msec.
Thus, the average axonal signal in Figure 3 leads the AMPA signal by 3 msec, of which 2 msec is average conduction time, and 1 msec is the
time to peak of a unitary EPSC [note that this 1 msec may also be on
the high side (Geiger et al., 1997)]. The AMPA signal leads the
voltage of the particular interneuron by 2.1 msec. Without the
conduction delays, the time from the axonal signal to firing of this
interneuron would hence be 3.1 msec, less if a faster EPSC time course
on interneurons were used.
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REFERENCES |
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Csicsvári J,
Hirase H,
Czurkó A,
Mamiya A,
Buzsáki G
(1999)
Oscillatory coupling of interneurons in the behaving rat.
J Neurosci
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Geiger JR,
Lübke J,
Roth A,
Frotscher M,
Jonas P
(1997)
Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse.
Neuron
18:1009-1023[Web of Science][Medline].
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