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Figure 3.
Behavioral outcomes of antisense oligonucleotide
experiments. A, Freezing to the chamber is significantly
decreased (asterisk, p < 0.05) by
unilateral infusions of antisense TrkA oligonucleotide into the medial
septal area as compared with unilateral infusions of randomized control
oligonucleotide. This was the outcome 1 week after training and 24 hr
after surgery. B, Freezing to the chamber is
significantly decreased (asterisk, p < 0.01) by bilateral infusions of antisense TrkA oligonucleotide into
the medial septal area as compared with bilateral infusions of
randomized control oligonucleotide. This was the outcome 1 week after
training and 24 hr after surgery. C, Freezing to the
chamber is significantly decreased (asterisk,
p < 0.05) by bilateral infusions of antisense TrkA
oligonucleotide into CA1 of the hippocampus as compared with bilateral
infusions of randomized control oligonucleotide. This was the outcome 1 week after training and 48 hr after surgery. D, Freezing
to the chamber is not affected by bilateral infusions of antisense TrkA
oligonucleotide into the medial septal area as compared with bilateral
infusions of randomized control oligonucleotide 4 weeks after training
and 24 hr after surgery. Error bars in A-D show the
SEM; 3-4 animals served as subjects in each group of the above
experiments.
