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The Journal of Neuroscience, May 1, 2002, 22(9):3332-3337

MINI REVIEW
Behavioral Neurobiology of Alcohol Addiction: Recent Advances and Challenges

Friedbert Weiss¹ and Linda J. Porrino²

¹ Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, and ² Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083

	ABSTRACT

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Addictive behavior associated with alcoholism is characterized by compulsive preoccupation with obtaining alcohol, loss of control over consumption, and development of tolerance and dependence, as well as impaired social and occupational functioning. Like other addictive disorders, alcoholism is characterized by chronic vulnerability to relapse after cessation of drinking. To understand the factors that compel some individuals to drink excessively, alcohol research has focused on the identification of brain mechanisms that support the reinforcing actions of alcohol and the progression of changes in neural function induced by chronic ethanol consumption that lead to the development of dependence. More recently, increasing attention has been directed toward the understanding of neurobiological and environmental factors in susceptibility to relapse.

	ARTICLE

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The conditions that lead to excessive alcohol consumption in some individuals and not in others are complex because they involve interactions among genetic, psychosocial, environmental, and neurobiological factors. In particular, alcoholism is a multigenic disorder. Animal models, including genetic models of alcoholism that may be relevant to some forms of alcoholism, and sophisticated genetic research strategies have been directed at this specific question. Moreover, in contrast to most other drugs of abuse, the actions of which are confined to a more limited number of neurochemical or receptor systems, the pharmacological effects of ethanol that support alcohol reward and alcohol-seeking behavior involve actions at multiple receptors and neurochemical systems occurring at widespread neuroanatomical sites throughout the brain. All of these factors together present unique challenges to understanding the basis of alcohol use and abuse. We focus here on recent information regarding the actions of ethanol on circuits implicated in motivation and reward, adaptations relevant for the transition to dependence and relapse, and issues relevant for the treatment of alcohol abuse that have provided new directions or new questions for the field of alcohol research.

Ethanol interactions with dopamine function in the mesolimbic "reward" pathway

Because ethanol acts as a positive reinforcer, focus on ethanol-induced activation of ventral tegmental area (VTA) dopamine (DA) function in the mesocorticolimbic reward pathway has prevailed. Other drugs of abuse have direct actions at DA synapses, but how ethanol affects this pathway has been a matter of some debate. Ethanol increases the firing of VTA DA neurons (Gessa et al., 1985; Brodie et al., 1990) through what has been shown recently to be direct excitatory cellular activation (Brodie et al., 1999). Like most drugs of abuse, ethanol elevates extracellular DA concentrations in the NAc (Di Chiara and Imperato, 1988), but recent evidence has linked this effect to direct actions at VTA DA somata rather than NAc DA terminals (Yim and Gonzales, 2000; Budygin et al., 2001).

Is activation of mesolimbic DA transmission a necessary condition for ethanol reward?

Early behavioral evidence (for review, see McBride and Li, 1998) that microinjection of ethanol into the VTA supports ethanol self-administration, ethanol dose-dependently increases DA release in the NAc in rats self-administering ethanol, and interference with DA transmission by microinjection of pharmacological agents into VTA or NAc reduces ethanol-reinforced responding has provided direct support for a role of DA in the reinforcing actions of ethanol. Manipulations of DA receptor gene expression and receptor knockout (KO) methodologies have supported this position. Mice deficient in DA D1 or D2 receptors and mice lacking DARPP-32, a phosphoprotein regulating D1 receptor function, consume less ethanol and show reduced ethanol-conditioned place preference (El-Ghundi et al., 1998; Cunningham et al., 2000; Risinger et al., 2000, 2001). Moreover, injection of D2 receptor antisense oligonucleotide into the NAc suppresses alcohol intake and reverses ethanol preference in a genetically selected line of high ethanol preferring rats (Myers and Robinson, 1999), pointing to the NAc as the critical site for attenuation of ethanol reward associated with DA D2 receptor deficiency.

On the other hand, DA lesion studies with the selective neurotoxin 6-hydroxydopamine (6-OHDA) consistently show that DA denervation of the NAc does not interfere with ethanol consumption or maintenance of ethanol-reinforced responding (Ikemoto et al., 1997; Koistinen et al., 2001). Similarly, elevation of NAc DA levels by a selective DA reuptake inhibitor fails to alter ethanol self-administration (Engleman et al., 2000). These results indicate that ethanol self-administration is not dependent on NAc DA activation. Possibly, compensatory adaptations after 6-OHDA lesions may substitute for loss of DA input to NAc, or, as suggested by imaging studies in rodents (Williams-Hemby and Porrino, 1997), stimulation of NAc DA transmission is necessary for rewarding effects associated with low-dose stimulant actions of ethanol but not essential for other aspects of reinforcing actions of ethanol (e.g., anxiolytic effects). Yet such effects may be sufficient to substitute for ethanol reward derived from its stimulant properties, or they may support ethanol-reinforced behavior in their own right.

Does DA function change with chronic ethanol exposure and withdrawal?

Over the course of chronic ethanol exposure, adaptations develop in mesolimbic DA function to counter sustained stimulation of this system by ethanol. Although ethanol acutely activates mesolimbic DA neurotransmission, withdrawal from chronic ethanol leads to substantial decrements in VTA DA neuron activity (Diana et al., 1992; Shen and Chiodo, 1993) and extracellular NAc DA levels (Rossetti et al., 1992; Weiss et al., 1996), suggesting that chronic ethanol exposure causes mesolimbic DA hypofunction, a condition significant for maintenance of addiction by promoting ethanol intake to compensate for its deceased efficacy on DA release and by motivating resumption of drinking during withdrawal to reverse DA deficits.

Recent findings have shed light on the mechanisms underlying DA dysregulation during chronic intoxication and withdrawal. Overactivity of L-type calcium channels is a possible mechanism for the suppression of DA release during ethanol withdrawal, because pharmacological inhibition of L-type calcium channels selectively blocks this withdrawal consequence (Rossetti et al., 1999). Decreased expression of tyrosine hydroxylase coupled with elevated levels of DA transporter (DAT) in rats maintained chronically on ethanol-containing diets suggests that decreases in DA synthesis and enhanced clearance of synaptic DA may cause DA hypofunction during ethanol dependence (Rothblat et al., 2001). The latter finding contrasts with results from human alcoholics in whom DAT binding is depressed significantly early in withdrawal but returns to normal with sustained abstinence (Laine et al., 1999). However, DAT binding in humans was measured after 4 d of withdrawal, whereas DAT expression in rats was determined before withdrawal. Thus, it remains to be determined whether decreased DAT binding is a consequence of chronic drinking or develops to compensate for reductions in DA release during ethanol withdrawal.

DA deficits in subjects with a history of dependence are not restricted to acute ethanol withdrawal but can be long-lasting, as suggested by reduced activity of VTA DA neurons after 3 d of withdrawal (Diana et al., 1996). Changes in NAc DA turnover and synthesis indicate that decreased DA release is present as long as 2 months after ethanol withdrawal (Bailey et al., 2000). The persistence of such abnormalities may have implications for vulnerability to relapse and adverse symptoms associated with protracted ethanol withdrawal. In clinical studies, a slow rate of recovery of DA receptor function predicts relapse and poor treatment outcome (Heinz et al., 1995). Unfortunately, in both the clinical and preclinical domain, systematic studies linking abnormalities in DA function during protracted withdrawal with ethanol-seeking or other relevant behavioral changes are sparse, but they are needed to understand the behavioral significance of persistent DA dysregulation in the abuse potential of ethanol.

Overall, current evidence suggests that mesolimbic DA transmission represents a substrate for the positive reinforcing actions of ethanol, most notably those associated with the mild stimulant actions of this drug. In addition, counteradaptive changes in mesolimbic dopamine function may provide a mechanism supporting the negative reinforcing aspects of ethanol associated with the dependent state as well as acute and protracted ethanol withdrawal.

Role of the extended amygdala in ethanol reinforcement

A novel target in the search for neural substrates of ethanol reinforcement is a group of interconnected basal forebrain structures called the extended amygdala, which extend from the NAc shell and bed nucleus of stria terminalis (BNST) to the central amygdala (CeA) (Alheid and Heimer, 1988). Opioid and GABA receptor antagonists administered into the NAc shell, BNST, or CeA reduce alcohol self-administration (Hyytiä and Koob, 1995; Heyser et al., 1999), implicating the extended amygdala in ethanol reinforcement. Ethanol enhances DA release in the CeA (Yoshimoto et al., 2000), and the BNST shows high sensitivity to DA-activating actions of drugs of abuse, including ethanol (Carboni et al., 2000). More direct evidence supporting a role for DA activation in these regions in drug reward exists, but only in the case of cocaine (Koob, 1999); the role of DA in the case of ethanol awaits confirmation by pharmacological and lesion studies.

Focus on the extended amygdala has also provided novel information implicating a role in negative reinforcement by ethanol that is associated with dependence and withdrawal. In addition to counteradaptive changes in neural systems implicated in ethanol positive reinforcement, neuroadaptations in systems not involved in acute reward may contribute to anxiety and other affective changes during withdrawal (Koob and Le Moal, 2001). The CeA and BNST, nuclei that contain a dense network of CRF immunoreactive cells (Swanson et al., 1983), may play a major role in these behavioral changes. Withdrawal from ethanol increases CRF release in CeA (Merlo Pich et al., 1995), and anxiety-like behavior associated with ethanol withdrawal is reduced by intracranial application of the CRF antagonist -helical CRF_9-41 (Rassnick et al., 1993) or by deletion of the CRF₁ receptor gene (Timpl et al., 1998). Measures of whole-tissue levels of CRF in the CeA indicate that dysregulation of this system after ethanol withdrawal is persistent (Zorrilla et al., 2001), although the behavioral significance of such changes remains to be established. Similar to the findings in the CeA, extracellular CRF levels in the BNST are elevated during acute ethanol withdrawal, and renewed ethanol consumption normalizes CRF release (Olive et al., 2002). Thus, to the extent that CRF hyperactivity in the BNST may contribute to anxiogenic consequences of ethanol withdrawal, the reversal of this effect by ethanol may contribute to the resumption and maintenance of addictive behavior.

Role of opioid systems in the addictive actions of ethanol

Interactions between ethanol and opioid systems have been an important focus of neurobiological research on alcohol addiction. Evidence for participation of opioid systems in modulation of ethanol-related behaviors comes from studies of opioid antagonist effects in animal models of ethanol seeking. Both nonselective opioid receptor antagonists and antagonists selective for µ- or -opioid receptors (MORs and DORs) reduce ethanol consumption and reinforced responding (for review, see Herz, 1997; Gianoulakis, 2001). Recent data from MOR KO mice favor a role of this receptor in ethanol reward because ethanol consumption, ethanol-reinforced operant responses, and ethanol-stimulated locomotion are decreased (Roberts et al., 2000; Hall et al., 2001). Ethanol self-administration is increased in DOR KO mice (Roberts et al., 2001), yet these mice exhibit an increased anxious-like phenotype, but reduced anxiety-like behavior is seen after ethanol self-administration. Thus, reversal of anxiety-like behavior is what may have led to the increased ethanol preference in these mice.

As for ethanol reinforcement, participation of opioid systems is not fully understood, but interactions with NAc DA transmission and DA-independent effects via opioid systems are implicated. Ethanol increases extracellular endorphins in the NAc, suggesting that attenuation of the reinforcing properties of ethanol by opioid antagonists may be related to inhibition of endogenous endorphin actions in the NAc (Olive et al., 2001). Reductions in voluntary drinking by intra-NAc administration of an opioid receptor antagonist (Heyser et al., 1999) or MOR antisense oligonucleotide (Myers and Robinson, 1999) suggest that these inhibitory effects may occur within the NAc. However, such effects may also be dependent on interactions with DA mechanisms. Both systemic (Benjamin et al., 1993) and focal (Acquas et al., 1993) administration of opioid receptor antagonists blunt ethanol-induced DA release within the NAc, implicating this effect in the suppression of ethanol intake by opioid antagonists (Gonzales and Weiss, 1998). On the other hand, selective lesions of DA terminals in the NAc do not alter ethanol self-administration in rats, but naltrexone reduced ethanol consumption in the same animals (Koistinen et al., 2001). Thus, mechanisms other than interference with DA transmission contribute to the suppressive effects of opiate antagonists on ethanol intake. Although the exact mechanisms by which ethanol increases NAc endorphin levels and by which opioid receptor antagonists exert suppressant effects on drinking have yet to be identified, these results indicate new directions for understanding the effectiveness of opioid receptor antagonists as pharmacological therapies for alcoholism.

On the basis of findings from animal models, naltrexone was tested and found to be effective as a treatment for alcoholism, in terms of both reducing ethanol consumption and preventing relapse (O'Malley et al., 1992; Volpicelli et al., 1992; Anton et al., 1999). However, a recent report (Krystal et al., 2001) cast doubt on the effectiveness of naltrexone. In this large multicenter, double-blind, placebo-controlled evaluation, naltrexone neither prevented nor delayed relapse, nor did it affect other outcome measures. Although this study questions the use of naltrexone, differences between this study and previous positive reports (mostly older men, and more severe alcoholism) likely account for the absence of positive effects. Understanding the neurobiological basis of the actions of naltrexone in human alcoholics, perhaps with new imaging technologies, as well as in animal models that consider the interactions of opioid systems with each stage of ethanol use and abuse, is key.

Incentive motivation, craving, and relapse

Conditioning of the rewarding effects of ethanol and other drugs of abuse with discrete stimuli is a major factor in abuse potential. Drug-related stimuli evoke drug desire that can lead to resumption of addictive behavior in abstinent individuals (O'Brien et al., 1998). Such stimuli may also elicit automatic responses that lead to drug-seeking and relapse without distinct feelings of craving. Thus, learned responses to drug-related stimuli may be a critical element in the chronic relapsing nature of ethanol and other drug addiction.

In animals, ethanol-associated contextual stimuli (Katner and Weiss, 1999; Ciccocioppo et al., 2001) consistently elicit recovery of responding at a previously ethanol-paired lever after extinction in the absence of further drug availability. Research using reinstatement procedures points to both DA and opioid systems in the motivating effects of ethanol-associated environmental stimuli. In rats, exposure to environments associated with ethanol availability increase extracellular NAc DA levels (Weiss et al., 1993; Gonzales and Weiss, 1998), and alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics (Braus et al., 2001), suggesting that mesolimbic DA transmission may have an important function in mediating behavior that brings the animal into contact with reinforcers. Such a role of DA may be relevant for the initiation of ethanol-seeking by alcohol cues and, by extension, ethanol craving and relapse. Indeed, appetitively motivated behavior preceding delivery of an ethanol solution is more sensitive to reversal by DA D2 receptor antagonists than behavior maintained by ethanol itself (Czachowski et al., 2001). Similarly, the conditioned reinforcing effects of a discrete stimulus previously paired with ethanol-reinforced responses are reversed by the DA receptor antagonist haloperidol (Wilson et al., 2000). A role of DA in relapse associated with exposure to alcohol cues has also been proposed. In rats tested for the response-reinstating effects of an alcohol-associated contextual stimulus after extinction of alcohol-reinforced behavior, blockade of either DA D1 or D2 receptors dose-dependently increases latency to initiate responding and reduces the number of responses at a previously active lever (Liu and Weiss, 2002). These effects of DA receptor blockade mesh well with an emerging view that the function of midbrain DA neurons is to convert motivational signals that predict reward into behavior directed at obtaining the predicted rewarding stimulus (Schultz et al., 1997).

The effects of ethanol-associated contextual stimuli in animal models of relapse are also sensitive to pharmacological manipulation of opioid receptors. The nonselective opioid receptor antagonist naltrexone, as well as MOR- and DOR-selective antagonists, reverses ethanol-seeking induced by ethanol-associated contextual stimuli (Katner et al., 1999; Ciccocioppo et al., 2002). Clearly, opioid receptors participate in ethanol-seeking motivated by drug cues. The fact that the MOR antagonist naloxonazine, but not the DOR antagonist naltrindole, produced nonselective behavioral suppression in these tasks suggests that DORs may be a target for treatment of alcohol craving and relapse (Ciccocioppo et al., 2002). These findings also have a bearing on the extinction hypothesis (Sinclair, 1990), which proposes that the anti-relapse actions of naltrexone are dependent on an associative component whereby subjects learn across repeated trials that ethanol is no longer reinforcing after opioid receptor antagonist administration. There is strong recent support for this hypothesis that has led to the suggestion that longer clinical use of naltrexone may be beneficial in reducing the number of relapse episodes (Stromberg et al., 1998). However, the "intrinsic" anti-relapse efficacy of opioid receptor antagonists in preventing ethanol-seeking after a single administration may also contribute to their clinical effectiveness.

Although the neurobiological basis of the ability of cues to produce reinstatement of drinking or drug seeking has been studied primarily in animal models, there are several recent reports of the neural correlates of craving for alcohol produced by olfactory and visual cues (Braus et al., 2001; Mann et al., 2001; Schneider et al., 2001). The results of these studies, however, have been somewhat variable. In one study (Schneider et al., 2001), the presentation of an alcohol olfactory stimulus to newly detoxified alcoholics produced activation within both the amygdala and cerebellum that was reversed by pharmacological and cognitive therapy. In contrast, a preliminary report assessing the effects of combined visual and olfactory stimuli to elicit craving in alcoholics identified cortical and thalamic loci (Mann et al., 2001), whereas a third study (Braus et al., 2001) reported effects in the ventral putamen. There is some similarity to the patterns of activation reported in cocaine users when exposed to various drug-related cues (Grant et al., 1996; Childress et al., 1999), but sample sizes and the kinds of paradigms used to elicit craving in alcoholics need to be expanded before we will obtain a consistent pattern of the substrates underlying cue-elicited ethanol craving.

Novel targets

Endocannabinoids

Recent evidence has shown that endogenous cannabinoids regulate ingestive behaviors via interactions with leptin (Di Marzo et al., 2001) as well as act as modulators of reward functions (De Vries et al., 2001). A number of reports now have begun to explore the specific relationship between ethanol and cannabinoid systems. Administration of the cannabinoid receptor antagonist, SR141716A, can decrease voluntary ethanol intake in mice (Arnone et al., 1997) as well as in alcohol-preferring rats (Colombo et al., 1998), where it can also prevent the acquisition of drinking behavior (Serra et al., 2001). CB1 receptors have also been shown to be involved in mediating appetitive and consummatory aspects of ethanol ingestion (Freedland et al., 2001), suggesting that SR141716A may have clinical utility in the treatment of alcohol abuse (Freedland et al., 2001). It may also be effective in the prevention of relapse, because SR141716A can be effective in inhibiting reinstatement of drug-seeking behavior elicited by cocaine or cocaine-related cues (De Vries et al., 2001). The mechanism responsible for the suppression of intake of ethanol and cocaine remains to be elucidated, although an interaction of cannabinoids with striatal DA (Giuffrida et al., 1999) is certainly a possibility, but the role of cannabinoids in leptin regulation should also be considered.

Neuropeptide Y

Neuropeptide Y (NPY), like endocannabinoids, is widely distributed throughout the brain (Dumont et al., 1992) and is involved in the control of food intake (Kalra et al., 1991). Of late, NPY has also been implicated in the regulation of ethanol consumption. NPY KO mice show increased voluntary consumption of ethanol, whereas overexpression of NPY yields the opposite result (Thiele et al., 1998). NPY KO mice were also less sensitive to ethanol-induced sedation, whereas mice overexpressing NPY had increased sleep times (Thiele et al., 1998). These effects are the result of interactions specifically with the Y1 NPY receptor subtype (Thiele et al., 2002). Consistent with these findings, rats bred for alcohol preference have reduced levels of NPY specifically within the CeA (Hwang et al., 1990), and the central infusion of exogenous NPY also decreases ethanol drinking in ethanol preferring rats (Badia-Elder et al., 2001). However, alterations of ethanol-related behaviors have not been shown when NPY was administered to nonpreferring or outbred rat strains (Slawecki et al., 2000; Badia-Elder et al., 2001), and the direct injection of NPY into the paraventricular nucleus of the hypothalamus actually increased ethanol consumption (Kelley et al., 2001). Site specificity may underlie these discrepancies, or it may be the case that NPY selectively alters the high ethanol intake of preferring rats via modulation of stress responses. Regardless of their exact mechanisms of action, both endocannabinoids and NPY are potential targets for the development of novel therapeutics for the treatment of alcohol abuse.

Concluding considerations

This review has focused on neurochemical systems and brain circuits that are relevant for alcohol addiction from the perspective of motivation and reinforcement. Ethanol alters synaptic transmission by modulating neuronal excitability through an interaction with ligand and voltage-gated ion channels. As a result, alcohol directly or indirectly affects the function of many neurotransmitter systems in the brain. These actions, and in particular the actions at GABA_A, NMDA, and serotonin 5-HT3 ionotropic receptors, are of central importance for the addictive effects of ethanol in addition to interactions with the neurochemical systems discussed here. As reviewed elsewhere, important advances have been made in the understanding of the mechanisms of these actions by ethanol and their relevance for alcohol intoxication, tolerance, dependence, and withdrawal (Grant and Lovinger, 1995; Woodward, 2000; Morrow et al., 2001). Understanding the integration of the interactions among these multiple systems in the regulation of ethanol-seeking behavior and the development of ethanol dependence is an important challenge for future research.

	FOOTNOTES

This work was supported by National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism through Grants AA 10531 and AA06420 (F.W.) and AA11997 and AA0929 (L.J.P.).

Correspondence should be addressed to Friedbert Weiss, Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037. E-mail: bweiss{at}scripps.edu.

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