Movie 3:

This movie shows the bizarre protrusion of the leading process of migrating cells under the treated with an anti-DCC Mab. The unidirectional movement of the leading process observed in Movie 1 is not seen in these cells. The slice is from a P3 mouse, and the tendency to meander without clear direction of the cells suggests that DCC plays a role of direction finding sensor. The movie corresponds to Figure 7E, and composed of 42 frames with 5 min intervals. Actual duration of the movie is 210 min.

Movie 3

Movie 4:

This time-lapse movie shows cells moving at the border between the end portion of the rostral migratory stream (RMS) and granule cell layer; that is, these cells are beginning to differentiate to mature neurons. The rapid movement of cells in the RMS is not found, but cells extend multi-branched leading processes without clear direction. The slice is from a P2 mouse, and the movie is composed of 153 frames with 5 min intervals. Actual duration is 765 min.

Movie 4